Lipid profile as a novel prognostic predictor for patients with acute myeloid leukemia

Frontiers in Oncology

Oncology

Ruonan Shao¹  Shujing Lu¹  Hua Wang¹  Jingzi Wang¹  Huizhong Wang¹  Bibo Fu¹  Shenrui Bai¹  Yue Lu¹ 

[1] State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China;

关键词: acute myeloid leukemia;    lipid profile;    blood chemical analysis;    prognostic factors;    predictive modeling;    dyslipdemia;   

DOI  :  10.3389/fonc.2023.950732

 received in 2022-05-23, accepted in 2023-01-16,  发布年份 2023

来源: Frontiers

【 摘 要 】

PurposeThis study investigated the relationship between serum lipid levels and clinical outcomes in acute myeloid leukemia (AML) by establishing a predictive risk classification model.MethodA total of 214 AML patients who were pathologically diagnosed and treated with standard induction chemotherapy at Sun Yat-Sen University Cancer Center were included. The patients were randomly divided into the training (n = 107) and validation (n=107) cohorts. Univariate and multivariate Cox analyses were used to assess the value of triglyceride (TG), Apolipoprotein B (Apo B), Apo Apolipoprotein A-I (Apo A-I), cholesterol (CHO), and high-density lipoprotein (HDL) as prognostic factors for AML.ResultsAfter a series of data analyses, a five-factor model was established to divide the patients into high- and low-risk groups. Kaplan-Meier survival analysis showed that the high-risk group had a poor prognosis (P<0.05). The area under the curve of the novel model for five-year OS was 0.737. A nomogram was constructed to integrate the model with age and the 2017 ELN cytogenetic classification, with the merged model showing improved accuracy with an area under the curve of 0.987 for five-year OS.ConclusionA novel model was constructed using a combination of the serum lipid profile and clinical characteristics of AML patients to enhance the predictive accuracy of clinical outcomes. The nomogram used the lipid profile which is routinely tested in clinical blood biochemistry and showed both specific prognostic and therapeutic potential.

【 授权许可】

Unknown   
Copyright © 2023 Bai, Wang, Shao, Fu, Lu, Wang, Lu and Wang