Microbiota alteration of Chinese young male adults with high-status negative cognitive processing bias

Frontiers in Microbiology

Microbiology

Xia Zhou¹  Xie He²  Zheng-Zhi Feng²  Tian-Yao Liu²  Hui-Min Xu³  Shen-Wei Xie⁴ 

[1] Daping Hospital, Army Medical University, Chongqing, China;Department of Medical Psychology, School of Psychology, Army Medical University, Chongqing, China;Department of Medical Psychology, School of Psychology, Army Medical University, Chongqing, China;Taiyuan Satellite Launch Center, Taiyuan, China;Department of Medical Psychology, School of Psychology, Army Medical University, Chongqing, China;The People’s Liberation Army (PLA) 953 Hospital, Army Medical University, Rìkazé, China;

关键词: negative cognitive processing bias (NCPB);    cognition;    microbiota;    depressive symptoms;    Faecalibaculum;    Chinese young male adults;   

DOI  :  10.3389/fmicb.2023.989162

 received in 2022-07-08, accepted in 2023-01-16,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionEvidence suggests that negative cognitive processing bias (NCPB) is a significant risk factor for depression. The microbiota–gut–brain axis has been proven to be a contributing factor to cognitive health and disease. However, the connection between microbiota and NCPB remains unknown. This study mainly sought to explore the key microbiota involved in NCPB and the possible pathways through which NCPB affects depressive symptoms.MethodsData in our studies were collected from 735 Chinese young adults through a cross-sectional survey. Fecal samples were collected from 35 young adults with different levels of NCPB (18 individuals were recruited as the high-status NCPB group, and another 17 individuals were matched as the low-status NCPB group) and 60 with different degrees of depressive symptoms (27 individuals were recruited into the depressive symptom group, as D group, and 33 individuals were matched into the control group, as C group) and analyzed by the 16S ribosomal RNA sequencing technique.ResultsAs a result, the level of NCPB correlated with the degree of depressive symptoms as well as anxiety symptoms and sleep quality (p < 0.01). The β-diversity of microbiota in young adults was proven to be significantly different between the high-status NCPB and the low-status NCPB groups. There were several significantly increased bacteria taxa, including Dorea, Christensenellaceae, Christe -senellaceae_R_7_group, Ruminococcaceae_NK4A214_group, Eggerthellaceae, Family-XIII, Family_XIII_AD3011_group, Faecalibaculum, and Oscillibacter. They were mainly involved in pathways including short-chain fatty acid (SCFA) metabolism. Among these variable bacteria taxa, Faecalibaculum was found associated with both NCPB and depressive symptoms. Furthermore, five pathways turned out to be significantly altered in both the high-status NCPB group and the depressive symptom group, including butanoate metabolism, glyoxylate and dicarboxylate metabolism, propanoate metabolism, phenylalanine, tyrosine, and tryptophan biosynthesis, valine, leucine, and isoleucine degradation. These pathways were related to SCFA metabolism.DiscussionFecal microbiota is altered in Chinese young male adults with high status NCPB and may be involved in the biochemical progress that influences depressive symptoms.

【 授权许可】

Unknown   
Copyright © 2023 Xu, Xie, Liu, Zhou, Feng and He.