Notch signaling: A potential target for the development of host-directed therapies against tuberculosis

Frontiers in Tropical Diseases

Tropical Diseases

Piyush Baindara¹ 

[1] Department of Radiation Oncology, School of Medicine, University of Missouri, Columbia, MO, United States;

关键词: Mycobacterium tuberculosis;    tuberculosis;    host-targets;    host-directed therapies;    infection;   

DOI  :  10.3389/fitd.2023.1100526

 received in 2022-11-16, accepted in 2023-02-27,  发布年份 2023

来源: Frontiers

【 摘 要 】

Tuberculosis (TB) is one of the preeminent causes of death among infectious diseases and remains a global threat to human health. Mycobacterium tuberculosis (Mtb) has coevolved with the human host and is an extremely successful pathogen by abusing the human system in different ways. Interestingly, Mtb can remain undetected in the human host for years as latent TB, so there is an urgent need to develop new therapies to combat Mtb. In the recent past, host-directed therapies have attracted the research community as a promising approach to combat TB, and thus novel host targets are of interest. In the present editorial, we have explored and suggested Notch signaling as a potential host target to develop a new therapeutic strategy against Mtb.

【 授权许可】

Unknown   
Copyright © 2023 Baindara