An update on animal models of liver fibrosis

Frontiers in Medicine

Medicine

FenYao Li¹  KeShen Li¹  WenBo Xing¹  Yan He¹  XinXin Wang¹  Ming Liang¹  ShuTing Wu¹  JianMing Wang² 

[1] Institute of Regenerative and Translational Medicine, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, China;Institute of Regenerative and Translational Medicine, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, China;Department of Hepatobiliary and Pancreatic Surgery, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, China;

关键词: liver fibrosis;    liver injury;    inflammation;    in vivo;    animal models;   

DOI  :  10.3389/fmed.2023.1160053

 received in 2023-02-07, accepted in 2023-03-06,  发布年份 2023

来源: Frontiers

【 摘 要 】

The development of liver fibrosis primarily determines quality of life as well as prognosis. Animal models are often used to model and understand the underlying mechanisms of human disease. Although organoids can be used to simulate organ development and disease, the technology still faces significant challenges. Therefore animal models are still irreplaceable at this stage. Currently, in vivo models of liver fibrosis can be classified into five categories based on etiology: chemical, dietary, surgical, transgenic, and immune. There is a wide variety of animal models of liver fibrosis with varying efficacy, which have different implications for proper understanding of the disease and effective screening of therapeutic agents. There is no high-quality literature recommending the most appropriate animal models. In this paper, we will describe the progress of commonly used animal models of liver fibrosis in terms of their development mechanisms, applications, advantages and disadvantages, and recommend appropriate animal models for different research purposes.

【 授权许可】

Unknown   
Copyright © 2023 Wu, Wang, Xing, Li, Liang, Li, He and Wang.