Pathogenesis and therapy of radiation enteritis with gut microbiota

Frontiers in Pharmacology

Pharmacology

Bingzhi Qin¹  Fang Yin¹  Huanlong Qin¹  Qilin Yang²  Weiliang Hou³ 

[1] Research Institute of Intestinal Diseases, Shanghai Tenth People’s Hospital, Tongji University, Shanghai, China;Research Institute of Intestinal Diseases, Shanghai Tenth People’s Hospital, Tongji University, Shanghai, China;School of Clinical Medicine of Nanjing Medical University, Nanjing, China;Research Institute of Intestinal Diseases, Shanghai Tenth People’s Hospital, Tongji University, Shanghai, China;Shanghai Cancer Institute, Renji Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, China;

关键词: radiotherapy;    radiation enteritis;    pathogenesis;    gut microbiota;    microbial therapy;   

DOI  :  10.3389/fphar.2023.1116558

 received in 2022-12-05, accepted in 2023-03-07,  发布年份 2023

来源: Frontiers

【 摘 要 】

Radiotherapy is widely used in clinic due to its good effect for cancer treatment. But radiotherapy of malignant tumors in the abdomen and pelvis is easy to cause radiation enteritis complications. Gastrointestinal tract contains numerous microbes, most of which are mutualistic relationship with the host. Abdominal radiation results in gut microbiota dysbiosis. Microbial therapy can directly target gut microbiota to reverse microbiota dysbiosis, hence relieving intestinal inflammation. In this review, we mainly summarized pathogenesis and novel therapy of the radiation-induced intestinal injury with gut microbiota dysbiosis and envision the opportunities and challenges of radiation enteritis therapy.

【 授权许可】

Unknown   
Copyright © 2023 Yang, Qin, Hou, Qin and Yin.