The pharmacokinetics and pharmacodynamics of esomeprazole in sheep after intravenous dosing

Frontiers in Veterinary Science

Veterinary Science

Joan Bergman¹  Lainey Harvill¹  Sherry Cox¹  Olivia Grace Escher²  Pierre-Yves Mulon²  Kailee Bennett²  Ryan Flynn²  Joe S. Smith³  Jessica Gebert⁴  Lisa Sams Ebner⁴  Amanda Jo Kreuder⁵ 

[1] Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, United States;Large Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, United States;Large Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, United States;Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, United States;Lincoln Memorial University, College of Veterinary Medicine, Harrogate, TN, United States;Veterinary Microbiology and Preventative Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, United States;

关键词: abomasal ulcer;    abomasal ulceration;    ewe;    gastric;    gastroprotectant;    proton pump inhibitor (PPI);   

DOI  :  10.3389/fvets.2023.1172023

 received in 2023-02-22, accepted in 2023-04-04,  发布年份 2023

来源: Frontiers

【 摘 要 】

Abomasal (gastric) ulceration is a morbidity in sheep, and currently, there is a paucity of pharmacokinetic and pharmacodynamic data for gastroprotectant drugs reported for this species. The proton pump inhibitor esomeprazole has been used in small animal and human patients for gastroprotection via increasing the gastric pH. The objective of this study was to report the pharmacokinetic parameters and pharmacodynamic effect of esomeprazole in sheep after single intravenous dosing. Four healthy adult Southdown cross ewes had blood collected over a 24  h time period after single intravenous dosing of esomeprazole at 1.0  mg/kg. Abomasal fluid was sampled over 24  h before and after esomeprazole administration. Plasma samples were analyzed for concentrations of esomeprazole and the esomeprazole metabolite, esomeprazole sulfone by high performance liquid chromatography. Pharmacokinetic and pharmacodynamic data were evaluated with specialized software. Esomeprazole was rapidly eliminated after IV administration. Elimination half-life, area under the curve, initial concentration (C0), and clearance were 0.2  h, 1,197  h*ng/mL, 4,321  ng/mL, and 0.83  mL/h/kg, respectively. For the sulfone metabolite elimination half-life, area under the curve and maximum concentration were 0.16  h, 22.5  h*ng/mL, and 65.0  ng/mL, respectively. Abomasal pH was significantly elevated from 1 to 6  h after administration and remained above 4.0 for at least 8 h after administration. No adverse effects were noted in these sheep. Esomeprazole was rapidly eliminated in sheep, similar to goats. Abomasal pH was increased, but future studies will be necessary to develop a clinical management approach to the use of esomeprazole in sheep.

【 授权许可】

Unknown   
Copyright © 2023 Smith, Gebert, Bennett, Ebner, Flynn, Mulon, Harvill, Escher, Kreuder, Bergman and Cox.