Aurora kinases: Generators of spatial control during mitosis

Frontiers in Cell and Developmental Biology

Cell and Developmental Biology

Aamir Ali¹  P. Todd Stukenberg² 

[1]Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia, Charlottesville, VA, United States

[2]null

关键词: Aurora kinases;    chromosome biorientation;    kinetochore-microtubule interactions;    kinase gradients;    mitosis;    nuclear envelope reformation;    mitotic spindle;    micronuclei;   

DOI  :  10.3389/fcell.2023.1139367

 received in 2023-01-06, accepted in 2023-03-02,  发布年份 2023

来源: Frontiers

【 摘 要 】

Cell division events require regulatory systems to ensure that events happen in a distinct order. The classic view of temporal control of the cell cycle posits that cells order events by linking them to changes in Cyclin Dependent Kinase (CDK) activities. However, a new paradigm is emerging from studies of anaphase where chromatids separate at the central metaphase plate and then move to opposite poles of the cell. These studies suggest that distinct events are ordered depending upon the location of each chromosome along its journey from the central metaphase plate to the elongated spindle poles. This system is dependent upon a gradient of Aurora B kinase activity that emerges during anaphase and acts as a spatial beacon to control numerous anaphase/telophase events and cytokinesis. Recent studies also suggest that Aurora A kinase activity specifies proximity of chromosomes or proteins to spindle poles during prometaphase. Together these studies argue that a key role for Aurora kinases is to provide spatial information that controls events depending upon the location of chromosomes or proteins along the mitotic spindle.

【 授权许可】

Unknown   
Copyright © 2023 Ali and Stukenberg.