Micro- and macro-changes in early-stage type 2 diabetes mellitus without cognitive impairment: a diffusion tensor imaging (DTI) and surface-based morphometry (SBM) study

Frontiers in Neurology

Neurology

Yanzi Chen¹  Xiangyong Tang¹  Ling Ding¹  Yuzhong Zhang¹  Dafei Yu¹  Jinzhi Fang¹  Ziqi Hu¹  Xiao Li¹  Cuimei Chen¹  Hui Tan² 

[1] Department of Medical Imaging, Affiliated Longhua People's Hospital, Southern Medical University, Shenzhen, China;Department of Medical Imaging, Second Affiliated Hospital, Shantou University Medical College, Shantou, China;

关键词: type 2 diabetes mellitus;    white matter;    cortex;    diffusion tenser imaging;    FreeSurfer;   

DOI  :  10.3389/fneur.2023.1115634

 received in 2022-12-04, accepted in 2023-05-26,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionBrain structure and function changes are considered major brain damages in type 2 diabetes mellitus (T2DM), which likely has a close relationship with cognitive impairment. Many previous studies have shown by using brain structural and functional magnetic resonance imaging (MRI) methods that brain white and gray matter are damaged in T2DM, leading to cognitive impairment. Researches neglected patients of T2DM without cognitive dysfunction might also have brain changes.MethodsIn this study, subjects with early stage T2DM with no cognitive dysfunction were enrolled to detect brain damages using the tract-based spatial statistics analysis (TBSS) method to demonstrate white matter (WM) micro changes and surface-based morphometry (SBM) method to assess cerebral cortex macro changes.ResultsThe whole-brain TBSS analysis revealed that there were no statistically significant changes in fractional anisotropy (FA) and mean diffusivity (MD), but the FA declined in some area of cerebral WM (p < 0.1). The SBM results showed no changes in cortical thickness (CT), cortical volume (CV), surface area (SA), and cortical sulcal curve (CSC) between these two groups, but pial local gyration index (LGI) was decreased in the precuneus (−log10, p = −3.327).DiscussionIn conclusion, early stage T2DM patients without cognitive impairment had brain micro and macro structural damages, suggesting the potential use of MRI as an imaging marker to detect brain changes in early stage T2DM, which could not be observed and assessed clinically.

【 授权许可】

Unknown   
Copyright © 2023 Tang, Chen, Tan, Fang, Yu, Chen, Li, Hu, Ding and Zhang.