Resistance mechanisms of tigecycline in Acinetobacter baumannii

Frontiers in Cellular and Infection Microbiology

Cellular and Infection Microbiology

Yunsong Yu¹  Chunli Sun²  Xiaoting Hua³ 

[1] Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China;Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, China;Regional Medical Center for National Institute of Respiratory Diseases, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China;Zhejiang University-University of Edinburgh (ZJU-UoE) Institute, Zhejiang University, Haining, Zhejiang, China;Zhejiang University-University of Edinburgh (ZJU-UoE) Institute, Zhejiang University, Haining, Zhejiang, China;Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China;Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, China;Regional Medical Center for National Institute of Respiratory Diseases, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China;

关键词: Acinetobacter baumannii;    resistance mechanism;    resistance;    tigecycline;    antibiotic;   

DOI  :  10.3389/fcimb.2023.1141490

 received in 2023-01-10, accepted in 2023-04-14,  发布年份 2023

来源: Frontiers

【 摘 要 】

Acinetobacter baumannii is widely distributed in nature and in hospital settings and is a common pathogen causing various infectious diseases. Currently, the drug resistance rate of A. baumannii has been persistently high, showing a worryingly high resistance rate to various antibiotics commonly used in clinical practice, which greatly limits antibiotic treatment options. Tigecycline and polymyxins show rapid and effective bactericidal activity against CRAB, and they are both widely considered to be the last clinical line of defense against multidrug resistant A. baumannii. This review focuses with interest on the mechanisms of tigecycline resistance in A. baumannii. With the explosive increase in the incidence of tigecycline-resistant A. baumannii, controlling and treating such resistance events has been considered a global challenge. Accordingly, there is a need to systematically investigate the mechanisms of tigecycline resistance in A. baumannii. Currently, the resistance mechanism of A. baumannii to tigecycline is complex and not completely clear. This article reviews the proposed resistance mechanisms of A. baumannii to tigecycline, with a view to providing references for the rational clinical application of tigecycline and the development of new candidate antibiotics.

【 授权许可】

Unknown   
Copyright © 2023 Sun, Yu and Hua