期刊论文详细信息
Frontiers in Molecular Biosciences
The effects of GPER on age-associated memory impairment induced by decreased estrogen levels
Molecular Biosciences
Yunpeng Cao1  Yanbo Zhang2  Wenyu Luo3  Yudie Yan3  Zhen Zhang3 
[1] Department of Neurology, The First Hospital of China Medical University, Shenyang, Liaoning, China;Department of Psychiatry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada;Department of Ultrasound, The First Hospital of China Medical University, Shenyang, Liaoning, China;
关键词: G protein-coupled estrogen receptor;    estrogen;    aging;    memory impairment;    neurogenesis;    synaptic plasticity;   
DOI  :  10.3389/fmolb.2023.1097018
 received in 2022-11-13, accepted in 2023-02-08,  发布年份 2023
来源: Frontiers
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【 摘 要 】

Estrogen, as a pleiotropic endocrine hormone, not only regulates the physiological functions of peripheral tissues but also exerts vital neuroregulatory effects in the central nervous system (CNS), such as the development of neurons and the formation of neural network connections, wherein rapid estrogen-mediated reactions positively stimulate spinogenesis and regulate synaptic plasticity and synaptic transmission to facilitate cognitive and memory performance. These fast non-genomic effects can be initiated by membrane-bound estrogen receptors (ERs), three best known of which are ERα, ERβ, and G protein-coupled estrogen receptor (GPER). To date, the effects of ERα and ERβ have been well studied in age-associated memory impairment, whereas there is still a lack of attention to the role of GPER in age-associated memory impairment, and there are still disputes about whether GPER indeed functions as an ER to enhance learning and memory. In this review, we provide a systematic overview of the role of GPER in age-associated memory impairment based on its expression, distribution, and signaling pathways, which might bring some inspiration for translational drugs targeting GPER for age-related diseases and update knowledge on the role of estrogen and its receptor system in the brain.

【 授权许可】

Unknown   
Copyright © 2023 Luo, Yan, Cao, Zhang and Zhang.

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