The role of Raptor in lymphocytes differentiation and function

Frontiers in Immunology

Immunology

Louisa K. James¹  Heather Miller²  Zhimin Zhai³  Niels Olsen Saraiva Camara⁴  Hu Zeng⁵  Steffen Heegaard⁶  Pamela Lee⁷  Chaohong Liu⁸  Fei Guan⁸  Jiahui Lei⁸  Jianing Tang⁸  Lu Yang⁸  Masato Kubo⁹  Chengwei He^1,10  Kamel Benlagha^1,11 

[1] Centre for Immunobiology, Bizard Institute, Queen Mary University of London, London, United Kingdom;Cytek Biosciences, R&D Clinical Reagents, Fremont, CA, United States;Department of Hematology, The Second Hospital of Anhui Medical University, Hefei, China;Department of Immunology, Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo, SP, Brazil;Department of Immunology, Mayo Clinic, Rochester, MN, United States;Division of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, MN, United States;Department of Ophthalmology, Rigshospitalet Glostrup, Copenhagen, Denmark;Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark;Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China;Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonostic Infectious Disease, Huazhong University of Science and Technology, Wuhan, Hubei, China;Laboratory for Cytokine Regulation, Center for Integrative Medical Science (IMS), Rikagaku Kenkyusho, Institute of Physical and Chemical Research (RIKEN) Yokohama Institute, Yokohama, Japan;State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao SAR, China;Université de Paris, Institut de Recherche Saint-Louis, EMiLy, Paris, France;

关键词: Raptor;    mTORC1;    T cell;    B cell;    immune;   

DOI  :  10.3389/fimmu.2023.1146628

 received in 2023-01-17, accepted in 2023-04-28,  发布年份 2023

来源: Frontiers

【 摘 要 】

Raptor, a key component of mTORC1, is required for recruiting substrates to mTORC1 and contributing to its subcellular localization. Raptor has a highly conserved N-terminus domain and seven WD40 repeats, which interact with mTOR and other mTORC1-related proteins. mTORC1 participates in various cellular events and mediates differentiation and metabolism. Directly or indirectly, many factors mediate the differentiation and function of lymphocytes that is essential for immunity. In this review, we summarize the role of Raptor in lymphocytes differentiation and function, whereby Raptor mediates the secretion of cytokines to induce early lymphocyte metabolism, development, proliferation and migration. Additionally, Raptor regulates the function of lymphocytes by regulating their steady-state maintenance and activation.

【 授权许可】

Unknown   
Copyright © 2023 Tang, Yang, Guan, Miller, Camara, James, Benlagha, Kubo, Heegaard, Lee, Lei, Zeng, He, Zhai and Liu