Strategic actions to advance multipurpose prevention technologies in low- and middle-income countries

Frontiers in Reproductive Health

Reproductive Health

Bethany Young Holt¹  Ariane van der Straten²  Taryn Barker³  Z. Mike Chirenje⁴  Joseph Romano⁵  Anne-Isabelle Cameron⁶  Carmen Pérez Casas⁶  Cherise Scott⁶ 

[1] CAMI Health, Initiative for MPTs, Public Health Institute, Sacramento, CA, United States;Center for AIDS Prevention Studies (CAPS), Department of Medicine, UCSF, San Francisco, CA, United States and ASTRA Consulting, Kensington, CA, United States;Children’s Investment Fund Foundation, London, United Kingdom;Department of Obstetrics and Gynecology, UCSF, San Francisco, CA, United States;NWJ, Group, LLC, Wayne, PA, United States;UNITAID, Geneva, Switzerland;

关键词: multipurpose prevention technologies;    MPTs;    HIV;    LMICs (low and middle income countries);    contraception;    STIs;   

DOI  :  10.3389/frph.2023.1150857

 received in 2023-01-25, accepted in 2023-05-25,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundHIV, other sexually transmitted infections (STIs) and unintended pregnancies are critical and interlinked health risks for millions of women of reproductive age worldwide. Multipurpose prevention technologies (MPTs) offer an innovative approach for expanding combined pregnancy and/or disease prevention. So far, MPT development efforts have focused mostly on HIV prevention, but about half of product candidates comprise compounds active against non-HIV STIs as well. This review aims to provide a framework that promotes the efficient advancement of the most promising preclinical products through the development pathway and into the hands of end-users, with a focus on women in low- and middle-income countries (L/MICs).MethodsThis mini review provides a summary of the current landscape of the MPT field. It comprises a landscape assessment of MPTs in development, complemented by a series of 28 in-depth, semi-structured key informant interviews (KIIs) with experts representing different L/MIC perspectives.Main resultsWe identified six primary action strategies to advance MPTs for L/MICs, including identification of key research gaps and priorities. For each action strategy, progress to date and key recommendations are included.ConclusionsTo realize the life-saving potential of MPTs and maximize the momentum made to date, a strategic, collaborative and well-funded response to the gaps and next steps outlined in this paper is critical. A coordinated response can add rigor and efficiency to the development process, to successfully advance the most promising MPT products to the hands of end-users.

【 授权许可】

Unknown   
© 2023 Young Holt, van der Straten, Barker, Chirenje, Cameron, Scott, Casas and Romano.