Case report: Effect of Hb E heterozygosity on HbA1c value by the Tosoh HLC-723G11

Frontiers in Public Health

Public Health

Nenggang Jiang¹  Wei Gao²  Wenyu Li²  Huairong Tang²  Qian Zheng³ 

[1]Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China

[2]Health Management Center, General Practice Center, West China Hospital, Sichuan University, Chengdu, China

[3]West China School of Medicine, Sichuan University, Chengdu, China

关键词: HbA1c;    Hb E;    heterozygosity;    high-pressure liquid chromatography;    Tosoh HLC-723G11;   

DOI  :  10.3389/fpubh.2023.1217662

 received in 2023-05-05, accepted in 2023-07-17,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectiveWe report the effect of Hb E heterozygosity on HbA1c value by the Tosoh HLC-723G11.Case reportA 45 years-old Chinese woman presented with an abnormally low HbA1c level of 3.7% (3.9%–6.1%) in a health examination. Fasting blood glucose was normal. Blood routine examination and serum bilirubin were in the normal range. HbA1c was determined by Tosoh HLC-723G11. There was an abnormal peak between A1c and A0 on the chromatogram. Hemoglobin electrophoresis indicated that the Hb E zone accounted for 25.1%. The β-thalassemia-related genes (mutant type) were βE M/N, and the related gene CD26 (A > G) was mutated. OGTT indicated prediabetes.ConclusionHb E heterozygosity may reduce HbA1c value with abnormal chromatograms, as determined by a Tosoh HLC G11 analyzer. The Tosoh HLC G11 analyzer can well identify Hb E variation. In this case, further blood glucose-related tests should be performed to avoid missed diagnoses. However, a large sample size is needed to confirm this conclusion.

【 授权许可】

Unknown   
Copyright © 2023 Gao, Li, Zheng, Jiang and Tang.