Clinical Significance and Risk Factors of Local Recurrence in Synovial Sarcoma: A Retrospective Analysis of 171 Cases

Frontiers in Surgery

Surgery

Wangjun Yan¹  Chunmeng Wang¹  Wending Huang¹  Yong Chen¹  Wei Sun¹  Lin Yu²  Qi Feng³  Jianing Zhang⁴  Kai Huang⁵  Hongqiang Zhang⁶  Xinglong Qu⁶ 

[1] Department of Musculoskeletal Oncology, Shanghai Cancer Center, Fudan University, Shanghai, China;Department of Oncology, Shanghai Medical College of Fudan University, Shanghai, China;Department of Oncology, Shanghai Medical College of Fudan University, Shanghai, China;Department of Pathology, Shanghai Cancer Center, Fudan University, Shanghai, China;Department of Orthopedics, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China;Department of Surgery Base, Shanghai Cancer Center, Fudan University, Shanghai, China;Department of Surgery, Brandon Regional Hospital, Morsani College of Medicine, Hospital Corporation of America Healthcare/University of South Florida Health, Tampa, FL, United States;Department of Surgical Oncology, Shanghai Cancer Center Minhang Branch Hospital, Fudan University, Shanghai, China;

关键词: synovial sarcoma;    local recurrence;    overall survival (OS);    prognosis;    risk factor;   

DOI  :  10.3389/fsurg.2021.736146

 received in 2021-08-15, accepted in 2021-12-08,  发布年份 2022

来源: Frontiers

【 摘 要 】

Objective: To investigate risk factors of local recurrence of synovial sarcoma and the impact of local recurrence on survival.Methods: We retrospectively reviewed clinical data of patients with II to IIIB (AJCC8) synovial sarcoma who underwent surgery at our center between March 2005 and December 2016. Data relating clinicopathological factors, treatment and prognosis were collected. The impact of local recurrence on overall survival (OS), local recurrence-free survival (LRFS), and distant relapse-free survival (DRFS) were analyzed. The prognostic factors associated with local recurrence were also analyzed using Kaplan-Meier Curves and Cox regression analysis.Results: A total of 171 patients were included in this analysis. After a median follow-up of 48 months, 66 patients (38.6%) experienced local recurrence. The 5-year OS, LRFS, and DRFS rates of patients with local recurrence were 37.6, 6.1, and 24.1%, respectively. Multivariate analysis showed that larger initial tumors, multiple recurrences, positive resection margins, marginal resection, and lack of adjuvant therapy were associated with higher local recurrence.Conclusion: Local recurrence of synovial sarcoma is associated with distant metastasis and poor survival. Chemoradiation improves the prognosis of patients with local recurrence, in particular those for which recurrence occurs shortly after initial treatment.

【 授权许可】

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Copyright © 2022 Zhang, Huang, Feng, Sun, Yan, Wang, Zhang, Huang, Yu, Qu and Chen.