Dose–response association of Chinese visceral adiposity index with comorbidity of hypertension and diabetes mellitus among elderly people

Frontiers in Endocrinology

Endocrinology

Lulu Cheng¹  Lingzhen Kong¹  Wei Yan¹  Ranran Qie²  Minghui Han³  Yicun Lei⁴  Zheng Li⁴  Yiduo Li⁴  Yongcheng Ren⁵ 

[1] Affiliated Hospital of Huanghuai University, Zhumadian Central Hospital, Zhumadian, He’nan, China;Department of Cancer Prevention and Control, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China;Institute of Health Data Management, Huanghuai University, Zhumadian, He’nan, China;Institute of Health Data Management, Huanghuai University, Zhumadian, He’nan, China;Affiliated Hospital of Huanghuai University, Zhumadian Central Hospital, Zhumadian, He’nan, China;Jiyuan Center for Disease Control and Prevention, Jiyuan, He’nan, China;

关键词: Chinese visceral adiposity index;    comorbidity;    mediation analysis;    elder people;    insulin resistance;   

DOI  :  10.3389/fendo.2023.1187381

 received in 2023-03-16, accepted in 2023-04-27,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundChinese visceral adiposity index (CVAI) is a reliable indicator of visceral obesity, but little is known about the association of CVAI with comorbidity of hypertension (HTN) and diabetes mellitus (DM). This study aimed to explore the associations of CVAI with HTN-DM comorbidity, HTN or DM, HTN, and DM in elderly people and evaluate the mediating role of insulin resistance in the associations.MethodsA total of 3,316 Chinese participants aged ≥60 years were included in this cross-sectional study. Logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic splines were applied to explore the dose–response associations. Mediation analyses were used to assess the mediating effect of triglyceride-glucose (TyG) index in the associations.ResultsThe prevalence rate of HTN-DM comorbidity, HTN or DM, HTN, and DM was 13.78%, 72.26%, 67.16%, and 18.88%, respectively. Linear associations between CVAI and HTN-DM comorbidity, HTN or DM, HTN, and DM were found, and ORs (95%CIs) were 1.45 (1.30–1.61), 1.39 (1.28–1.52), 1.36 (1.25–1.48), and 1.28 (1.16–1.41) for per SD increase in CVAI. Compared with quartile 1 of CVAI, the risk of HTN-DM comorbidity, HTN or DM, HTN, and DM increased 190%, 125%, 112%, and 96% for quartile 4. In addition, we found TyG index playing a key role in the associations of CVAI with HTN-DM comorbidity, HTN or DM, and DM.ConclusionCVAI is linearly and positively correlated with HTN-DM comorbidity, HTN or DM, HTN, and DM. The potential mechanism is insulin resistance largely mediating the associations.

【 授权许可】

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Copyright © 2023 Ren, Cheng, Qie, Han, Kong, Yan, Li, Li and Lei