Post-COVID-19 syndrome and diabetes mellitus: a propensity-matched analysis of the International HOPE-II COVID-19 Registry

Frontiers in Endocrinology

Endocrinology

Martino Pepe¹  Aitor Uribarri²  Javier López-País³  Olalla Vazquez Cancela⁴  Christel Weiß⁵  Ibrahim Akin⁶  Mohammad Abumayyaleh⁶  Ibrahim El-Battrawy⁷  Francesco Santoro⁸  Lazar Velicki⁹  Víctor Manuel Becerra-Muñoz^1,10  David Chipayo^1,11  Antonio Fernandez-Ortiz^1,11  Iván J. Núñez Gil^1,11  Francisco Marín^1,12  Jaime Signes-Costa^1,13  Alex Fernando Castro Mejía^1,14  Gisela Feltes^1,15  Rodolfo Romero^1,16  María C. Viana-LLamas^1,17  Adelina Gonzalez^1,18  Alvaro López Masjuan^1,19  Carolina Espejo Paeres^2,20  Emilio Alfonso-Rodríguez^2,21  Edoardo Manzone^2,22  Sergio Raposeiras Roubin^2,23 

[1] Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, Bari, Italy;Cardiology Department, Vall d’Hebron University Hospital and Research Institute, Universitat Autonoma de Barcelona, Barcelona, Spain;Centro de Investigacion Biomedica en Red para Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain;Complejo Hospitalario Universitario de Ourense, Ourense, Spain;Complejo Hospitalario Universitario de Santiago de Compostela, Santiago, Spain;Department for Statistical Analysis, University Heidelberg, Mannheim, Germany;Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany;European Center for AngioScience (ECAS) and German Center for Cardiovascular Research (DZHK) partner site Heidelberg/Mannheim, Mannheim, Germany;Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany;European Center for AngioScience (ECAS) and German Center for Cardiovascular Research (DZHK) partner site Heidelberg/Mannheim, Mannheim, Germany;Department of Cardiology and Angiology, Bergmannsheil University Hospitals, Ruhr University of Bochum, Bochum, Germany;Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy;Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia;Institute of Cardiovascular Diseases Vojvodina, Sremska Kamenica, Serbia;Hospital Clinico Universitario Virgen de la Victoria, Malaga, Spain;Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación, Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain;Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain;Hospital Clínico de Valencia, INCLIVA, Valencia, Spain;Hospital General del norte de Guayaquil IESS Los Ceibos, Guayaquil, Ecuador;Hospital Nuestra Señora de América, Madrid, Spain;Hospital Universitario Getafe, Getafe, Universidad Europea, Madrid, Spain;Hospital Universitario Guadalajara, Guadalajara, Spain;Hospital Universitario Infanta Sofia, Madrid, Spain;Hospital Universitario Juan Ramón Jimenez, Huelva, Spain;Hospital Universitario Príncipe de Asturias, Madrid, Spain;Hospital University of Bellvitge, Barcelona, Spain;Hospital del Sureste, Madrid, Spain;University Hospital Álvaro Cunqueiro, Vigo, Spain;

关键词: diabetes mellitus;    post-COVID-19 syndrome;    SARS-CoV-2;    respiratory complications;    reinfection;    vaccination rate;    long-term mortality;   

DOI  :  10.3389/fendo.2023.1167087

 received in 2023-02-15, accepted in 2023-04-27,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundDiabetes mellitus (DM) is one of the most frequent comorbidities in patients suffering from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with a higher rate of severe course of coronavirus disease (COVID-19). However, data about post-COVID-19 syndrome (PCS) in patients with DM are limited.MethodsThis multicenter, propensity score-matched study compared long-term follow-up data about cardiovascular, neuropsychiatric, respiratory, gastrointestinal, and other symptoms in 8,719 patients with DM to those without DM. The 1:1 propensity score matching (PSM) according to age and sex resulted in 1,548 matched pairs.ResultsDiabetics and nondiabetics had a mean age of 72.6 ± 12.7 years old. At follow-up, cardiovascular symptoms such as dyspnea and increased resting heart rate occurred less in patients with DM (13.2% vs. 16.4%; p = 0.01) than those without DM (2.8% vs. 5.6%; p = 0.05), respectively. The incidence of newly diagnosed arterial hypertension was slightly lower in DM patients as compared to non-DM patients (0.5% vs. 1.6%; p = 0.18). Abnormal spirometry was observed more in patients with DM than those without DM (18.8% vs. 13; p = 0.24). Paranoia was diagnosed more frequently in patients with DM than in non-DM patients at follow-up time (4% vs. 1.2%; p = 0.009). The incidence of newly diagnosed renal insufficiency was higher in patients suffering from DM as compared to patients without DM (4.8% vs. 2.6%; p = 0.09). The rate of readmission was comparable in patients with and without DM (19.7% vs. 18.3%; p = 0.61). The reinfection rate with COVID-19 was comparable in both groups (2.9% in diabetics vs. 2.3% in nondiabetics; p = 0.55). Long-term mortality was higher in DM patients than in non-DM patients (33.9% vs. 29.1%; p = 0.005).ConclusionsThe mortality rate was higher in patients with DM type II as compared to those without DM. Readmission and reinfection rates with COVID-19 were comparable in both groups. The incidence of cardiovascular symptoms was higher in patients without DM.

【 授权许可】

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Copyright © 2023 Abumayyaleh, Núñez Gil, Viana-LLamas, Raposeiras Roubin, Romero, Alfonso-Rodríguez, Uribarri, Feltes, Becerra-Muñoz, Santoro, Pepe, Castro Mejía, Signes-Costa, Gonzalez, Marín, López-País, Manzone, Vazquez Cancela, Paeres, Masjuan, Velicki, Weiß, Chipayo, Fernandez-Ortiz, El-Battrawy, Akin, HOPE COVID-19 investigators