Single-cell transcriptome sequencing reveals heterogeneity of gastric cancer: progress and prospects

Frontiers in Oncology

Oncology

Sha Liu¹  Sicheng Liang¹  Muhan Lü¹  Xu Zhang¹  Yonglan Chen¹  Gaohua Deng¹  Zehui Yu² 

[1] Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China;Laboratory Animal Center, Southwest Medical University, Luzhou, Sichuan, China;

关键词: single-cell RNA sequencing;    gastric cancer;    tumor heterogeneity;    oncogenesis;    individualized therapy;   

DOI  :  10.3389/fonc.2023.1074268

 received in 2022-10-19, accepted in 2023-05-11,  发布年份 2023

来源: Frontiers

【 摘 要 】

Gastric cancer is one of the most serious malignant tumor and threatens the health of people worldwide. Its heterogeneity leaves many clinical problems unsolved. To treat it effectively, we need to explore its heterogeneity. Single-cell transcriptome sequencing, or single-cell RNA sequencing (scRNA-seq), reveals the complex biological composition and molecular characteristics of gastric cancer at the level of individual cells, which provides a new perspective for understanding the heterogeneity of gastric cancer. In this review, we first introduce the current procedure of scRNA-seq, and discuss the advantages and limitations of scRNA-seq. We then elaborate on the research carried out with scRNA-seq in gastric cancer in recent years, and describe how it reveals cell heterogeneity, the tumor microenvironment, oncogenesis and metastasis, as well as drug response in to gastric cancer, to facilitate early diagnosis, individualized therapy, and prognosis evaluation.

【 授权许可】

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Copyright © 2023 Deng, Zhang, Chen, Liang, Liu, Yu and Lü