Oral fructose intake does not improve exercise, visual, or cognitive performance during acute normobaric hypoxia in healthy humans

Frontiers in Nutrition

Nutrition

Sven Haufe¹  Uwe Tegtbur¹  Andreas Peter²  Andreas L. Birkenfeld³  Petra Frings-Meuthen⁴  Ann C. Ewald⁴  Cayla Denney⁴  Titiaan E. Post⁵  Dominik Pesta⁶  Riccardo De Gioannis⁷  Jan Schmitz⁸  Henning Weis⁹  Daniel Aeschbach^1,10  Jens Jordan^1,11 

[1] Clinic for Rehabilitation and Sports Medicine, Hannover Medical School, Hannover, Germany;Department for Diagnostic Laboratory Medicine, Institute for Clinical Chemistry and Pathobiochemistry, University Hospital Tübingen, Tübingen, Germany;Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany;German Center for Diabetes Research (DZD), Neuherberg, Germany;Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany;German Center for Diabetes Research (DZD), Neuherberg, Germany;Division of Diabetology, Endocrinology, and Nephrology, Department of Internal Medicine, Eberhard Karls University Tübingen, Tübingen, Germany;Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany;Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany;Centre for Human Drug Research (CHDR), Leiden, Netherlands;Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany;Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany;Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany;Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany;Department III for Internal Medicine, Faculty of Medicine, Heart Center, University Hospital of Cologne, Cologne, Germany;Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany;Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany;Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany;Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany;Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany;Institute of Experimental Epileptology and Cognition Research, University of Bonn Medical Center, Bonn, Germany;Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany;Medical Faculty, University of Cologne, Cologne, Germany;

关键词: normobaric hypoxia;    fructose;    exercise performance;    visual performance;    cognitive performance;   

DOI  :  10.3389/fnut.2023.1170873

 received in 2023-02-21, accepted in 2023-07-04,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionThe ability to metabolize fructose to bypass the glucose pathway in near-anaerobic conditions appears to contribute to the extreme hypoxia tolerance of the naked-mole rats. Therefore, we hypothesized that exogenous fructose could improve endurance capacity and cognitive performance in humans exposed to hypoxia.MethodsIn a randomized, double-blind, crossover study, 26 healthy adults (9 women, 17 men; 28.8 ± 8.1 (SD) years) ingested 75 g fructose, 82.5 g glucose, or placebo during acute hypoxia exposure (13% oxygen in a normobaric hypoxia chamber, corresponding to oxygen partial pressure at altitude of ~3,800 m) on separate days. We measured exercise duration, heart rate, SpO2, blood gasses, and perceived exertion during a 30-min incremental load test followed by Farnsworth-Munsell 100 Hue (FM-100) color vision testing and the unstable tracking task (UTT) to probe eye-hand coordination performance.ResultsExercise duration in hypoxia was 21.13 ± 0.29 (SEM) min on fructose, 21.35 ± 0.29 min on glucose, and 21.35 ± 0.29 min on placebo (p = 0.86). Heart rate responses and perceived exertion did not differ between treatments. Total error score (TES) during the FM-100 was 47.1 ± 8.0 on fructose, 45.6 ± 7.6 on glucose and 53.3 ± 9.6 on placebo (p = 0.35) and root mean square error (RMSE) during the UTT was 15.1 ± 1.0, 15.1 ± 1.0 and 15.3 ± 0.9 (p = 0.87).DiscussionWe conclude that oral fructose intake in non-acclimatized healthy humans does not acutely improve exercise performance and cognitive performance during moderate hypoxia. Thus, hypoxia tolerance in naked mole-rats resulting from oxygen-conserving fructose utilization, cannot be easily reproduced in humans.

【 授权许可】

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Copyright © 2023 Post, Schmitz, Denney, De Gioannis, Weis, Pesta, Peter, Birkenfeld, Haufe, Tegtbur, Frings-Meuthen, Ewald, Aeschbach and Jordan.