Effect of smoking on the development of chronic obstructive pulmonary disease in young individuals: a nationwide cohort study

Frontiers in Medicine

Medicine

Sei Won Lee¹  Chiwook Chung²  Kyu Na Lee³  Kyungdo Han³  Dong Wook Shin⁴ 

[1] Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea;Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea;Department of Pulmonary, Allergy, and Critical Care Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Republic of Korea;Department of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of Korea;Supportive Care Center, Samsung Comprehensive Cancer Center, Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;

关键词: cigarette smoking;    smoker;    young age;    female;    COPD;   

DOI  :  10.3389/fmed.2023.1190885

 received in 2023-03-21, accepted in 2023-07-20,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundCigarette smoking is an important risk factor for developing chronic obstructive pulmonary disease (COPD). However, the effect of smoking on the development of COPD in young individuals remains unclear. We aimed to evaluate the effect of smoking on COPD development in young individuals.MethodsUsing the Korean National Health Information Database, we screened individuals aged 20–39 years who participated in the national health check-up between 2009 and 2012. We defined physician-diagnosed COPD based on health insurance claims and searched the database until December 2019. We identified 6,307,576 eligible individuals, and 13,789 had newly developed COPD. We used multivariate Cox proportional hazards models to estimate the adjusted hazard ratio (aHR) of risk factors for COPD.ResultsThe incidence rate for developing COPD was 0.26/1000 person-year. The risk of developing COPD was significantly higher in current smokers [aHR 1.46, 95% confidence interval (CI) 1.39–1.53] and former smokers (aHR 1.21, 95% CI 1.14–1.29) than in non-smokers. Furthermore, the risk increased with increasing smoking amounts (≥20 pack-years, aHR 2.24; 10–20 pack-years, aHR 1.55; <10 pack-years, aHR 1.27). Female participants had a higher relative risk of developing COPD due to smoking, compared with their male counterparts.ConclusionCigarette smoking increased the risk of developing COPD in young individuals. Current and heavy smokers had higher risks of developing COPD than non-smokers. Female smokers were more likely to develop COPD than male smokers.

【 授权许可】

Unknown   
Copyright © 2023 Chung, Lee, Han, Shin and Lee.