Characterization and potential of periosteum-derived cells: an overview

Frontiers in Medicine

Medicine

Fang Guo¹  Haoxin Pan¹  Kun Song¹  Yujie Cao¹  Beibei Chen²  Rongkai Cao² 

[1] Department of Stomatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China;Stomatological Hospital and Dental School of Tongji University, Shanghai, China;

关键词: periosteum-derived cells;    isolation;    characterization;    osteogenic;    chondrogenic;    adipogenic;   

DOI  :  10.3389/fmed.2023.1235992

 received in 2023-06-07, accepted in 2023-07-10,  发布年份 2023

来源: Frontiers

【 摘 要 】

As a thin fibrous layer covering the bone surface, the periosteum plays a significant role in bone physiology during growth, development and remodeling. Over the past several decades, the periosteum has received considerable scientific attention as a source of mesenchymal stem cells (MSCs). Periosteum-derived cells (PDCs) have emerged as a promising strategy for tissue engineering due to their chondrogenic, osteogenic and adipogenic differentiation capacities. Starting from the history of PDCs, the present review provides an overview of their characterization and the procedures used for their isolation. This study also summarizes the chondrogenic, osteogenic, and adipogenic abilities of PDCs, serving as a reference about their potential therapeutic applications in various clinical scenarios, with particular emphasis on the comparison with other common sources of MSCs. As techniques continue to develop, a comprehensive analysis of the characterization and regulation of PDCs can be conducted, further demonstrating their role in tissue engineering. PDCs present promising potentials in terms of their osteogenic, chondrogenic, and adipogenic capacities. Further studies should focus on exploring their utility under multiple clinical scenarios to confirm their comparative benefit over other commonly used sources of MSCs.

【 授权许可】

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Copyright © 2023 Cao, Chen, Song, Guo, Pan and Cao.