A cytocompatible microporous Sr-doped titanium dioxide coating fabricated by plasma electrolytic oxidation

Frontiers in Materials

Materials

Shuangjun He¹  Lijian Zhou¹  Hongming Zheng¹  Boyi Jiang¹  Jintao Yuan²  Xiaohui Ni²  Kaihang Lu³  Pengpeng Zhang³  Quanming Zhao³ 

[1] Department of Orthopedic Surgery, the People’s Hospital of Danyang, Danyang, Jiangsu, China;Department of Orthopedics, Dafeng People’s Hospital, Yancheng, Jiangsu, China;Department of Orthopedics, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China;

关键词: titanium;    plasma electrolytic oxidation;    surface characterization;    coating;    biological activity;   

DOI  :  10.3389/fmats.2023.1210728

 received in 2023-04-23, accepted in 2023-05-26,  发布年份 2023

来源: Frontiers

【 摘 要 】

Titanium has broad application prospects in the field of hard bone tissue repair and replacement due to its low density, an elastic modulus similar to that of human bone, and better biocompatibility than stainless steel and cobalt-based alloys. However, titanium is a biologically inert material with low biological activity. After implantation, it only physically bonds with bone instead of chemically bonding, which causes complications such as implant loosening. In this study, a strontium-doped titanium dioxide coating was prepared on a titanium surface with micro-arc oxidation. Based on a systematic study of the surface properties of the strontium-doped titanium dioxide coating, the biocompatibility and bioactivity of the coating were evaluated with in vitro cell experiments. The results showed that the strontium-doped titanium dioxide coating was successfully prepared on the titanium surface and exhibited strong bonding with the substrate. The coating surface had a porous structure, and the strontium was dispersed on the surface and inside the coating. The strontium ions were released slowly, which improved the corrosion and wear resistance of the titanium. In vitro cell experiments showed that the coating had good cell compatibility; it promoted the adhesion, proliferation and differentiation of MC3T3-E1 cells and exhibited good biological activity. These results showed that preparation of a strontium-doped titanium dioxide coating by micro-arc oxidation is feasible. The coating had a good surface morphology, improved the biological activity of the titanium and has good potential for clinical application.

【 授权许可】

Unknown   
Copyright © 2023 Zheng, He, Zhou, Yuan, Jiang, Ni, Lu, Zhang and Zhao.