Association between per- and polyfluoroalkyl substances and risk of hypertension: a systematic review and meta-analysis

Frontiers in Public Health

Public Health

Xiaoyi Sun¹  Xuehui Liu²  Junli Lv³  Yi Liu³  Heming Sun³  Ziwen An³  Fang Xiao³  Huicai Guo⁴ 

[1] Department of Occupational and Environmental Health, School of Public Health, Hebei Medical University, Shijiazhuang, China;Department of Occupational and Environmental Health, School of Public Health, Hebei Medical University, Shijiazhuang, China;Hebei Key Laboratory of Environment and Human Health, Shijiazhuang, China;Department of Toxicology, School of Public Health, Hebei Medical University, Shijiazhuang, China;Department of Toxicology, School of Public Health, Hebei Medical University, Shijiazhuang, China;Hebei Key Laboratory of Environment and Human Health, Shijiazhuang, China;

关键词: per-and polyfluoroalkyl substances;    hypertension;    high blood pressure;    meta-analysis;    environmental pollutants;   

DOI  :  10.3389/fpubh.2023.1173101

 received in 2023-02-24, accepted in 2023-06-27,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundExisting evidence indicates that exposure to per- and polyfluoroalkyl substances (PFASs) may increase the risk of hypertension, but the findings are inconsistent. Therefore, we aimed to explore the relationship between PFASs and hypertension through this systematic review and meta-analysis.MethodsWe searched PubMed, Embase, and the Web of Science databases for articles published in English that examined the relationship between PFASs and hypertension before 13 August 2022. The random effects model was used to aggregate the evaluation using Stata 15.0 for Windows. We also conducted subgroup analyses by region and hypertension definition. In addition, a sensitivity analysis was carried out to determine the robustness of the findings.ResultsThe meta-analysis comprised 15 studies in total with 69,949 individuals. The risk of hypertension was substantially and positively correlated with exposure to perfluorooctane sulfonate (PFOS) (OR = 1.31, 95% CI: 1.14, 1.51), perfluorooctanoic acid (PFOA) (OR = 1.16, 95% CI: 1.07, 1.26), and perfluorohexane sulfonate (PFHxS) (OR = 1.04, 95% CI: 1.00, 1.09). However, perfluorononanoic acid (PFNA) exposure and hypertension were not significantly associated (OR = 1.08, 95% CI: 0.99, 1.17).ConclusionWe evaluated the link between PFASs exposure and hypertension and discovered that higher levels of PFOS, PFOA, and PFHxS were correlated with an increased risk of hypertension. However, further high-quality population-based and pathophysiological investigations are required to shed light on the possible mechanism and demonstrate causation because of the considerable variability.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/ PROSPERO, registration number: CRD 42022358142.

【 授权许可】

Unknown   
Copyright © 2023 Xiao, An, Lv, Sun, Sun, Liu, Liu and Guo.