期刊论文详细信息
Frontiers in Pharmacology
Okra ameliorates hyperglycaemia in pre-diabetic and type 2 diabetic patients: A systematic review and meta-analysis of the clinical evidence
Pharmacology
Sogolo Lucky Lebelo1  Kabelo Mokgalaboni1  Saba Ghaffary2  Perpetua Modjadji3 
[1] Department of Life and Consumer Sciences, College of Agriculture and Environmental Sciences, Florida Campus, University of South Africa, Roodepoort, South Africa;Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;Non-Communicable Disease Research Unit, South African Medical Research Council, Cape Town, South Africa;Department of Public Health, School of Healthcare Sciences, Sefako Makgatho Health Sciences University, Ga-Rankuwa, South Africa;
关键词: okra;    antioxidant;    type 2 diabetes;    inflammation;    hyperglycaemia;    pre-diabetes;   
DOI  :  10.3389/fphar.2023.1132650
 received in 2022-12-27, accepted in 2023-03-22,  发布年份 2023
来源: Frontiers
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【 摘 要 】

Background: Despite the use of available pharmaceutical drugs, high rates of metabolic diseases and cardiovascular disorders are alarming. This calls for alternative therapies that can attenuate these complications. Therefore, we investigated the beneficial effects of okra on glycaemic control in pre-diabetes and type 2 diabetes mellitus (T2D).Methods: MEDLINE and Scopus were searched for relevant studies. Collected data were analysed using RevMan and reported as mean difference and 95% confidence intervals (CI). Eight studies, including 331 patients with pre-diabetes or T2D, were eligible.Results: Our findings showed that okra treatment reduced the levels of fasting blood glucose: mean difference (MD) = −14.63 mg/dL; 95% CI (-25.25, −4.00, p = 0.007); I2 = 33%, p = 0.17 compared to placebo. Glycated haemoglobin, however, did not differ significantly between the groups: MD = 0.01%; 95%CI (-0.51, 0.54, p = 0.96); I2 = 23%, p = 0.28.Conclusion: this systematic review and meta-analysis found that okra treatment improves glycaemic control in patients with pre-diabetes or T2D. The findings suggest that okra may be used as a supplemental dietary nutrient, especially in pre-diabetic and T2D patients due to its potential to regulate hyperglycaemia.

【 授权许可】

Unknown   
Copyright © 2023 Mokgalaboni, Lebelo, Modjadji and Ghaffary.

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