Regulatory mechanisms of microRNAs in endocrine disorders and their therapeutic potential

Frontiers in Genetics

Genetics

Antara Banerjee¹  Surajit Pathak¹  Asim K. Duttaroy²  Estefania Rodriguez-Jacinto³  Carolina Estrada-Meza³  S. Janin Ledesma-Pacheco³  Sujay Paul³  Elizabeth Gomez-Hernandez³  Andrea G. Uriostegui-Pena³  Luis M. Ruiz-Manriquez⁴ 

[1] Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Department of Medical Biotechnology, Faculty of Allied Health Sciences, Chennai, India;Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway;Tecnologico de Monterrey, School of Engineering and Sciences, Queretaro, Mexico;Tecnologico de Monterrey, School of Engineering and Sciences, Queretaro, Mexico;Tecnologico de Monterrey, Escuela de Medicina, Monterrey, Mexico;

关键词: miRNAs;    endocrine disorders;    diabetes mellitus;    thyroid diseases;    osteoporosis;    pituitary tumors;   

DOI  :  10.3389/fgene.2023.1137017

 received in 2023-01-03, accepted in 2023-02-09,  发布年份 2023

来源: Frontiers

【 摘 要 】

MicroRNAs (miRNAs) are small endogenous non-coding RNA molecules capable of regulating gene expression at the post-transcriptional level either by translational inhibition or mRNA degradation and have recently been importantly related to the diagnosis and prognosis of the most relevant endocrine disorders. The endocrine system comprises various highly vascularized ductless organs regulating metabolism, growth and development, and sexual function. Endocrine disorders constitute the fifth principal cause of death worldwide, and they are considered a significant public health problem due to their long-term effects and negative impact on the patient’s quality of life. Over the last few years, miRNAs have been discovered to regulate various biological processes associated with endocrine disorders, which could be advantageous in developing new diagnostic and therapeutic tools. The present review aims to provide an overview of the most recent and significant information regarding the regulatory mechanism of miRNAs during the development of the most relevant endocrine disorders, including diabetes mellitus, thyroid diseases, osteoporosis, pituitary tumors, Cushing’s syndrome, adrenal insufficiency and multiple endocrine neoplasia, and their potential implications as disease biomarkers.

【 授权许可】

Unknown   
Copyright © 2023 Ledesma-Pacheco, Uriostegui-Pena, Rodriguez-Jacinto, Gomez-Hernandez, Estrada-Meza, Banerjee, Pathak, Ruiz-Manriquez, Duttaroy and Paul.