Association of the gut microbiota with clinical variables in obese and lean Emirati subjects

Frontiers in Microbiology

Microbiology

Gabi Wazz¹  Koen Venema²  Carole Ayoub Moubareck³  Tarek Mahdy⁴  Mirey Karavetian⁵  Manal Ali Ahmad⁶ 

[1] Center of Excellence in Bariatric and Metabolic Surgery, Dr. Sulaiman Al Habib Hospital, Dubai, United Arab Emirates;Centre for Healthy Eating and Food Innovation (HEFI), Maastricht University-Campus Venlo, Venlo, Netherlands;College of Natural and Health Sciences, Zayed University, Dubai, United Arab Emirates;Department of Bariatric Surgery, Sharjah University, Sharjah, United Arab Emirates;Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, Canada;School of Nutrition and Translational Research in Metabolism (NUTRIM), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, Netherlands;

关键词: gut microbiota;    obesity;    firmicutes;    bacteroidetes;    16S rRNA;    United Arab Emirates;   

DOI  :  10.3389/fmicb.2023.1182460

 received in 2023-03-10, accepted in 2023-08-01,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundGrowing evidence supports the role of gut microbiota in obesity, yet exact associations remain largely unknown. Specifically, very little is known about this association in the Emirati population.MethodsWe explored differences in gut microbiota composition, particularly the Firmicutes/Bacteroidetes (F/B) ratio, between 43 obese and 31 lean adult Emirate counterparts, and its association with obesity markers, by using V3-V4 regions of 16 S ribosomal RNA gene sequencing data. Furthermore, we collected anthropometric and biochemical data.ResultsThe two major phyla in obese and lean groups were Firmicutes and Bacteroidetes. We observed a significantly lower alpha diversity (Shannon index) in obese subjects and a significant difference in beta diversity and phylum and genus levels between the two groups. The obese group had higher abundances of Verrucomicrobia and Saccharibacteira and lower abundances of Lentisphaerae. Acidaminococcus and Lachnospira were more abundant in obese subjects and positively correlated with adiposity markers. No correlations were found between the gut microbiota and biochemical variables, such as fasting blood sugar, total cholesterol, HDL cholesterol, LDL cholesterol, and triglycerides.ConclusionWe reveal significant differences in the gut microbiota between obese and lean adult Emiratis and an association between certain microbial genera of the gut microbiota and obesity. A better understanding of the interactions between gut microbes, diet, lifestyle, and health is warranted.

【 授权许可】

Unknown   
Copyright © 2023 Ahmad, Karavetian, Moubareck, Wazz, Mahdy and Venema.