The application of metagenomic next-generation sequencing in pathogen diagnosis: a bibliometric analysis based on Web of Science

Frontiers in Cellular and Infection Microbiology

Cellular and Infection Microbiology

Neng Wang¹  Liyu Chen¹  Ying Xiong²  Dan Liu²  Jingwen Wei³  Jiaming Feng³  Sike He³ 

[1] Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China;Department of Periodical Press, West China Hospital, Sichuan University, Chengdu, China;West China School of Medicine, Sichuan University, Chengdu, China;

关键词: metagenomic next-generation sequencing;    pathogen diagnosis;    bibliometric analysis;    Web of Science;    VOSviewer;    CiteSpace;   

DOI  :  10.3389/fcimb.2023.1112229

 received in 2022-11-30, accepted in 2023-07-18,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundInfectious disease is a large burden on public health globally. Metagenomic next-generation sequencing (mNGS) has become popular as a new tool for pathogen diagnosis with numerous advantages compared to conventional methods. Recently, research on mNGS increases yearly. However, no bibliometric analysis has systematically presented the full spectrum of this research field. Therefore, we reviewed all the publications associated with this topic and performed this study to analyze the comprehensive status and future hotspots of mNGS for infectious disease diagnosis.MethodsThe literature was searched in the Web of Science Core Collection and screened without year or language restrictions, and the characteristics of the studies were also identified. The outcomes included publication years, study types, journals, countries, authorship, institutions, frontiers, and hotspots with trends. Statistical analysis and visualization were conducted using VOSviewer (version 1.6.16) and CiteSpace (version 6.1. R3).ResultsIn total, 325 studies were included in the analysis after screening. Studies were published between 2009 and 2022 with a significantly increasing number from 1 to 118. Most of the studies were original articles and case reports. Frontiers in Cellular and Infection Microbiology and Clinical Infectious Disease were the most commonly cited and co-cited journals. Institutions and researchers from China contributed the most to this field, followed by those from the USA. The hotspots and frontiers of these studies are pneumonia, tuberculosis, and central nervous system infections.ConclusionThis study determined that mNGS is a hot topic in the diagnosis of infectious diseases with development trends and provides insights into researchers, institutions, hotspots and frontiers in mNGS, which can offer references to related researchers and future research.

【 授权许可】

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Copyright © 2023 He, Wei, Feng, Liu, Wang, Chen and Xiong