Development, stabilization, and characterization of nanoemulsion of vitamin D3-enriched canola oil

Frontiers in Nutrition

Nutrition

Muhammad Umair Arshad¹  Aafia Khalid¹  Ali Imran¹  Syed Haroon Khalid²  Mohd Asif Shah³ 

[1] Department of Food Science, Government College University, Faisalabad, Pakistan;Department of Pharmaceutics, Government College University, Faisalabad, Pakistan;School of Business, Woxsen University, Hyderabad, Telangana, India;Division of Research and Development, Lovely Professional University, Phagwara, Punjab, India;School of Engineering and Technology, Sharda University, Greater Noida, India;Department of Economics, Kabridahar University, Somali, Ethiopia;

关键词: nanoemulsion;    canola oil;    water titration techniques;    vitamin D fortification;    bioavailability;   

DOI  :  10.3389/fnut.2023.1205200

 received in 2023-04-13, accepted in 2023-07-17,  发布年份 2023

来源: Frontiers

【 摘 要 】

In this study, the oil-in-water nanoemulsion (NE) was prepared and loaded with vitamin D3 in food-grade (edible) canola oil and stabilized by Tween 80 and Span 80 by using a water titration technique with droplet sizes of 20 to 200 nm. A phase diagram was established for the influence of water, oil, and S-Mix concentration. The outcomes revealed that the particle size of blank canola oil nanoemulsion (NE) ranged from 60.12 to 62.27 (d.nm) and vitamin D3 NE ranged from 93.92 to 185.5 (d.nm). Droplet size and polydispersity index (PDI) of both blank and vitamin D3-loaded NE results were less than 1, and zeta potential results for blank and vitamin D3 loaded NE ranged from −9.71 to −15.32 mV and −7.29 to −13.56 mV, respectively. Furthermore, the pH and electrical conductivity of blank NE were 6.0 to 6.2 and 20 to 100 (μs/cm), respectively, whereas vitamin D3-loaded NE results were 6.0 to 6.2 and 30 to 100 (μs/cm), respectively. The viscosity results of blank NE ranged from 0.544 to 0.789 (mPa.s), while that of vitamin D3-loaded NE ranged from 0.613 to 0.793 (mPa.s). In this study, the long-term stability (3 months) of canola oil NE containing vitamin D3 at room temperature (25 C) and high temperature (40 C) was observed.

【 授权许可】

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Copyright © 2023 Khalid, Arshad, Imran, Haroon Khalid and Shah.