Associations between serum trace elements and the risk of nasopharyngeal carcinoma: a multi-center case-control study in Guangdong Province, southern China

Frontiers in Nutrition

Nutrition

Hang-Ning Zhou¹  Shang-Hang Xie¹  Wenjie Chen¹  Xin-Yu Ge²  Xueqi Li²  Su-Mei Cao³  Hao Wang⁴  Xin Ye⁵  Ai-Hua Lin⁵ 

[1] Department of Cancer Prevention Center, Sun Yat-sen University Cancer Center, Guangzhou, China;Department of Cancer Prevention Center, Sun Yat-sen University Cancer Center, Guangzhou, China;School of Public Health, Sun Yat-sen University, Guangzhou, China;Department of Cancer Prevention Center, Sun Yat-sen University Cancer Center, Guangzhou, China;State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, China;Department of Colorectal Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China;School of Public Health, Sun Yat-sen University, Guangzhou, China;

关键词: cadmium (Cd);    manganese (Mn);    nasopharyngeal carcinoma (NPC);    head and neck cancer;    logistic regression;    restricted cubic splines;    odds ratio;    trace element (TE);   

DOI  :  10.3389/fnut.2023.1142861

 received in 2023-01-12, accepted in 2023-04-05,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundAssociations between trace elements and nasopharyngeal carcinoma (NPC) have been speculated but not thoroughly examined.MethodsThis study registered a total of 225 newly diagnosed patients with NPC and 225 healthy controls matched by sex and age from three municipal hospitals in Guangdong Province, southern China between 2011 and 2015. Information was collected by questionnaire on the demographic characteristics and other possibly confounding lifestyle factors. Eight trace elements and the level of Epstein–Barr virus (EBV) antibody were measured in casual (spot) serum specimens by inductively coupled plasma–mass spectrometry (ICP-MS) and enzyme-linked immunosorbent assay (ELISA), respectively. Restricted cubic splines and conditional logistic regression were applied to assess the relationship between trace elements and NPC risk through single-and multiple-elements models.ResultsSerum levels of chromium (Cr), cobalt (Co), nickel (Ni), arsenic (As), strontium (Sr) and molybdenum (Mo) were not associated with NPC risk. Manganese (Mn) and cadmium (Cd) were positively associated with NPC risk in both single-and multiple-element models, with ORs of the highest tertile compared with the reference categories 3.90 (95% CI, 1.27 to 7.34) for Mn and 2.30 (95% CI, 1.26 to 3.38) for Cd. Restricted cubic splines showed that there was a linear increasing trend between Mn and NPC risk, while for Cd there was a J-type correlation.ConclusionSerum levels of Cd and Mn was positively related with NPC risk. Prospective researches on the associations of the two trace elements with NPC ought to be taken into account within the future.

【 授权许可】

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Copyright © 2023 Ge, Xie, Wang, Ye, Chen, Zhou, Li, Lin and Cao.