Targeting protein glycosylation to regulate inflammation in the respiratory tract: novel diagnostic and therapeutic candidates for chronic respiratory diseases

Frontiers in Immunology

Immunology

Siyuan Kong¹  Xiaofeng Xie¹  Weiqian Cao² 

[1] Shanghai Fifth People’s Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China;Shanghai Fifth People’s Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China;NHC Key Laboratory of Glycoconjugates Research, Fudan University, Shanghai, China;

关键词: protein glycosylation;    chronic respiratory diseases;    abnormal glycoenzyme activity;    glycoproteomics;    glycobiomarkers;   

DOI  :  10.3389/fimmu.2023.1168023

 received in 2023-02-17, accepted in 2023-05-02,  发布年份 2023

来源: Frontiers

【 摘 要 】

Protein glycosylation is a widespread posttranslational modification that can impact the function of proteins. Dysregulated protein glycosylation has been linked to several diseases, including chronic respiratory diseases (CRDs). CRDs pose a significant public health threat globally, affecting the airways and other lung structures. Emerging researches suggest that glycosylation plays a significant role in regulating inflammation associated with CRDs. This review offers an overview of the abnormal glycoenzyme activity and corresponding glycosylation changes involved in various CRDs, including chronic obstructive pulmonary disease, asthma, cystic fibrosis, idiopathic pulmonary fibrosis, pulmonary arterial hypertension, non-cystic fibrosis bronchiectasis, and lung cancer. Additionally, this review summarizes recent advances in glycomics and glycoproteomics-based protein glycosylation analysis of CRDs. The potential of glycoenzymes and glycoproteins for clinical use in the diagnosis and treatment of CRDs is also discussed.

【 授权许可】

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