Association between remnant cholesterol and chronic kidney disease in Chinese hypertensive patients

Frontiers in Endocrinology

Endocrinology

Wei Zhou¹  Lingjuan Zhu¹  Tao Wang¹  Chao Yu¹  Xinlei Zhou²  Chong Xie²  Congcong Ding²  Ting Yuan²  Yanyou Xie²  Huihui Bao³  Xiaoshu Cheng³ 

[1] Center for Prevention and Treatment of Cardiovascular Diseases, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China;Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center, Nanchang, Jiangxi, China;Jiangxi Sub-center of National Clinical Research Center for Cardiovascular Diseases, Nanchang, Jiangxi, China;Department of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China;Center for Prevention and Treatment of Cardiovascular Diseases, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China;Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center, Nanchang, Jiangxi, China;Department of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China;Center for Prevention and Treatment of Cardiovascular Diseases, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China;Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center, Nanchang, Jiangxi, China;Jiangxi Sub-center of National Clinical Research Center for Cardiovascular Diseases, Nanchang, Jiangxi, China;

关键词: remnant cholesterol;    chronic kidney disease;    Chinese hypertensive population;    cross-sectional study;    lipid metabolism;   

DOI  :  10.3389/fendo.2023.1189574

 received in 2023-03-19, accepted in 2023-06-02,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundRemnant cholesterol (RC) and chronic kidney disease (CKD) have not been definitively linked in individuals with different characteristics. This study aims to investigate the relationship between serum RC level and CKD and examine possible effect modifiers in Chinese patients with hypertension.MethodsOur study is based on the Chinese H-type Hypertension Project, which is an observational registry study conducted in real-world settings. The outcome was CKD, defined as an estimated glomerular filtration rate of less than 60 ml/min·1.73 m2. Multivariate logistic regression and smooth curve fitting were used to analyze the association between RC and CKD. Subgroup analyses were subsequently conducted to examine the effects of other variables.ResultsThe mean age of the 13,024 patients with hypertension at baseline was 63.8 ± 9.4 years, and 46.8% were male. A conspicuous linear positive association was observed between RC level and CKD (per SD increment; odds ratio [OR], 1.15; 95% confidence interval [CI], 1.08–1.23). Compared with the lowest quartile group of RC, the risk of CKD was 53% higher (OR, 1.53; 95% CI, 1.26–1.86) in the highest quartile group. Furthermore, a stronger positive association between RC level and CKD was found among participants with a higher body mass index (BMI <24 vs. ≥24 kg/m2; P-interaction = 0.034) or current non-smokers (smoker vs. non-smoker; P-interaction = 0.024).ConclusionsAmong Chinese adults with hypertension, RC level was positively associated with CKD, particularly in those with a BMI of ≥24 kg/m2 and current non-smokers. These findings may help improve lipid management regimens in patients with hypertension.

【 授权许可】

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Copyright © 2023 Yuan, Ding, Xie, Zhou, Xie, Wang, Yu, Zhou, Zhu, Bao and Cheng