Subsequent maternal sleep deprivation aggravates neurobehavioral abnormalities, inflammation, and synaptic function in adult male mice exposed to prenatal inflammation

Frontiers in Behavioral Neuroscience

Neuroscience

Meng-Ying Zhang¹  Xue-Yan Li²  Yi-Jun Ge²  Gui-Hai Chen²  Kai-Xuan Zhang²  Bao-Ling Luo²  Yue-Ming Zhang²  Ru-Meng Wei²  Jing-Ya Zhang²  Xiao-Yi Kong² 

[1] Department of Anesthesiology, The Affiliated Chaohu Hospital of Anhui Medical University, Hefei, Anhui, China;Department of Neurology (Sleep Disorders), The Affiliated Chaohu Hospital of Anhui Medical University, Hefei, Anhui, China;

关键词: maternal sleep deprivation;    lipopolysaccharide;    inflammation;    synaptic proteins;    anxiety;    depression;    cognition;   

DOI  :  10.3389/fnbeh.2023.1226300

 received in 2023-05-21, accepted in 2023-07-07,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectiveStudies have suggested that prenatal exposure to inflammation increases the risk of neuropsychiatric disorders, including anxiety, depression, and cognitive dysfunction. Because of anatomical and hormonal alterations, pregnant women frequently experience sleep dysfunction, which can enhance the inflammatory response. The aim of this study was to explore the effects of maternal sleep deprivation on prenatal inflammation exposure-induced behavioral phenotypes in offspring and identify the associated mechanisms.MethodsPregnant mice received an intraperitoneal injection of lipopolysaccharide (LPS) on gestational day 15 and were subsequently subjected to sleep deprivation during gestational days 15–21. Anxiety-like behavior was evaluated by the open field test and the elevated plus maze test. Depression-like behavior was assessed by the tail suspension test and the forced swimming test. Cognitive function was determined using the Morris water maze test. The levels of markers of inflammation and synaptic function were examined employing general molecular biological techniques.ResultsThe results showed that prenatal exposure to LPS resulted in anxiety- and depression-like symptoms and learning and memory deficits, and these effects were exacerbated by maternal sleep deprivation. Furthermore, maternal sleep deprivation aggravated the prenatal LPS exposure-induced increase in the expression of interleukin (IL)-1β, IL-6, and tumor necrosis factor-α and decrease in the levels of postsynaptic density-95 and synaptophysin in the hippocampus.DiscussionCollectively, these results suggested that maternal sleep deprivation exacerbates anxiety, depression, and cognitive impairment induced by prenatal LPS exposure, effects that were associated with an inflammatory response and synaptic dysfunction.

【 授权许可】

Unknown   
Copyright © 2023 Zhang, Zhang, Wei, Zhang, Zhang, Luo, Ge, Kong, Li and Chen.