Dissecting the regulatory network of transcription factors in T cell phenotype/functioning during GVHD and GVT

Frontiers in Immunology

Immunology

Mobin Karimi¹  Rebecca Harris¹ 

[1] Department of Microbiology and Immunology, State University of New York (SUNY) Upstate Medical University, Syracuse, NY, United States;

关键词: GVHD;    GVL;    allotransplantation;    transcription factors;    regulatory networks;   

DOI  :  10.3389/fimmu.2023.1194984

 received in 2023-03-27, accepted in 2023-06-13,  发布年份 2023

来源: Frontiers

【 摘 要 】

Transcription factors play a major role in regulation and orchestration of immune responses. The immunological context of the response can alter the regulatory networks required for proper functioning. While these networks have been well-studied in canonical immune contexts like infection, the transcription factor landscape during alloactivation remains unclear. This review addresses how transcription factors contribute to the functioning of mature alloactivated T cells. This review will also examine how these factors form a regulatory network to control alloresponses, with a focus specifically on those factors expressed by and controlling activity of T cells of the various subsets involved in graft-versus-host disease (GVHD) and graft-versus-tumor (GVT) responses.

【 授权许可】

Unknown   
Copyright © 2023 Harris and Karimi