Computerized working memory training for hypertensive individuals with executive function impairment: a randomized clinical trial

Frontiers in Neuroscience

Neuroscience

Danielle Irigoyen da Costa¹  Naomi Vidal Ferreira²  Brenno Cabella³  Regina Silva Paradela⁴  Maria Claudia Irigoyen⁴  Luiza Menoni Martino⁴  Luiz Aparecido Bortolotto⁴  Laura Aló Torres⁴  Fernanda Marciano Consolim-Colombo⁴  Mariana Penteado Nucci⁵ 

[1] Brain Institute (InsCer), Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil;Division of Geriatrics, University of São Paulo Medical School, São Paulo, Brazil;Research Affairs Office, Amazonia Adventist College, Benevides, Pará, Brazil;Institute of Theoretical Physics, São Paulo State University (IFT-UNESP), São Paulo, Brazil;Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil;Laboratory of Medical Investigations on Magnetic Resonance Imaging (LIM-44), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil;

关键词: executive function;    cognitive dysfunction;    rehabilitation;    hypertension;    magnetic resonance imaging;   

DOI  :  10.3389/fnins.2023.1185768

 received in 2023-03-14, accepted in 2023-06-21,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundHypertension is associated with working memory (WM) impairment. However, the benefits of Cogmed WM training for the hypertensive population are unknown. Therefore, we aimed to evaluate Cogmed’s effects on the WM performance of hypertensive individuals with executive function (EF) impairment.MethodsWe included 40 hypertensive patients (aged 40–70 years, 68% female) with EF impairment. They were randomized in a 1:1 ratio to receive 10 weeks of adaptive Cogmed training or a non-adaptive control training based on online games. The primary outcome was the WM performance. The secondary outcomes were verbal memory, visuospatial ability, executive function, global cognition, and the neuronal activity measured using functional magnetic resonance imaging (fMRI) under two WM task conditions: low (memorization of 4 spatial locations) and high (memorization of 6 spatial locations). An intention-to-treat (ITT) and per-protocol (PP) analysis were performed.ResultsCogmed did not show a significant effect on WM or any other cognitive outcome post-training. However, under the WM-low load and WM-high load conditions of the fMRI, respectively, the Cogmed group had an activation decrease in the right superior parietal lobe (ITT and PP analyses) and left inferior frontal lobe (PP analysis) in comparison to the control group.ConclusionThe Cogmed showed no effects on the WM performance of hypertensive individuals with EF impairment. However, activation decreases were observed in frontoparietal areas related to the WM network, suggesting a more efficient neuronal activity after training.

【 授权许可】

Unknown   
Copyright © 2023 Paradela, Cabella, Nucci, Ferreira, Torres, Martino, Consolim-Colombo, Bortolotto, da Costa and Irigoyen.