Cell type-specific roles of NLRP3, inflammasome-dependent and -independent, in host defense, sterile necroinflammation, tissue repair, and fibrosis

Frontiers in Immunology

Immunology

Tamisa Seeko Bandeira Honda¹  Hans-Joachim Anders¹  John Ku¹ 

[1] Division of Nephrology, Department of Medicine IV, Ludwig-Maximilians-University Hospital Munich, Munich, Germany;

关键词: inflammation;    infection;    regulated necrosis;    innate immunity;    interleukin;   

DOI  :  10.3389/fimmu.2023.1214289

 received in 2023-04-29, accepted in 2023-06-27,  发布年份 2023

来源: Frontiers

【 摘 要 】

The NLRP3 inflammasome transforms a wide variety of infectious and non-infectious danger signals that activate pro-inflammatory caspases, which promote the secretion of IL-1β and IL-18, and pyroptosis, a pro-inflammatory form of cell necrosis. Most published evidence documents the presence and importance of the NLRP3 inflammasome in monocytes, macrophages, and neutrophils during host defense and sterile forms of inflammation. In contrast, in numerous unbiased data sets, NLRP3 inflammasome-related transcripts are absent in non-immune cells. However, an increasing number of studies report the presence and functionality of the NLRP3 inflammasome in almost every cell type. Here, we take a closer look at the reported cell type-specific expression of the NLRP3 inflammasome components, review the reported inflammasome-dependent and -independent functions, and discuss possible explanations for this discrepancy.

【 授权许可】

Unknown   
Copyright © 2023 Honda, Ku and Anders