Initial low-dose computed tomography screening results and summary of participant characteristics: based on the latest Chinese guideline

Frontiers in Oncology

Oncology

Binrong Ding¹  Shaohui Liu²  Xuewei Zhang³  Yinyan Gao⁴  Zixuan Zhang⁴  Irene X. Y. Wu⁵ 

[1] Department of Geriatrics, The Third Xiangya Hospital, Central South University, Changsha, China;Health Management Center, Xiangya Hospital, Central South University, Changsha, China;Health Management Center, Xiangya Hospital, Central South University, Changsha, China;Centre for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, China;National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China;Xiangya School of Public Health, Central South University, Changsha, China;Xiangya School of Public Health, Central South University, Changsha, China;Hunan Provincial Key Laboratory of Clinical Epidemiology, Changsha, China;

关键词: lung cancer;    screening;    low-dose computed tomography;    non-smokers;    characteristics;   

DOI  :  10.3389/fonc.2023.1085434

 received in 2022-10-31, accepted in 2023-05-05,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundLow-dose computed tomography (LDCT) has been promoted as a promising screening strategy for early detection of lung cancer. China released the latest lung cancer screening guideline in 2021. The compliance of the individuals who received LDCT for lung cancer screening with the guideline is unknown yet. It is necessary to summarize the distribution of guideline-defined lung cancer–related risk factors in the Chinese population so as to inform the selection of target population for the future lung cancer screening.MethodsA single-center, cross-sectional study design was adopted. All participants were individuals who underwent LDCT at a tertiary teaching hospital in Hunan, China, between 1 January and 31 December 2021. LDCT results were derived along with guideline-based characteristics for descriptive analysis.ResultsA total of 5,486 participants were included. Over one-quarter (1,426, 26.0%) of the participants who received screening did not meet the guideline-defined high-risk population, even among non-smokers (36.4%). Most of the participants (4,622, 84.3%) were found to have lung nodules, while no clinical intervention was required basically. The detection rate of positive nodules varied from 46.8% to 71.2% when using different cut-off values for positive nodules. Among non-smoking women, ground glass opacity appeared to be more significantly common compared with non-smoking men (26.7% vs. 21.8%).ConclusionOver one-quarter of individuals who received LDCT screening did not meet the guideline-defined high-risk populations. Appropriate cut-off values for positive nodules need to be continuously explored. More precise and localized criteria for high-risk individuals are needed, especially for non-smoking women.

【 授权许可】

Unknown   
Copyright © 2023 Zhang, Gao, Liu, Ding, Zhang and Wu