期刊论文详细信息
Frontiers in Physiology
Aortic hemodynamic and morphological analysis before and after repair of thoracoabdominal aortic aneurysm using a G-Branch endograft
Physiology
Tingting Fan1  Dan Rong2  Yangyang Ge2  Wei Guo2  Hongpeng Zhang2  Feng Liu2  Weihang Lu2  Jiabin Wang3 
[1] School of Biomedical Engineering, Capital Medical University, Beijing, China;The First Medical Centre, Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, Beijing, China;The First Medical Centre, Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, Beijing, China;Medical School of Chinese PLA, Beijing, China;
关键词: multibranched stent graft;    thoracoabdominal aortic aneurysm;    hemodynamics;    morphology;    thoracic endovascular aortic repair;   
DOI  :  10.3389/fphys.2023.1234989
 received in 2023-06-05, accepted in 2023-07-19,  发布年份 2023
来源: Frontiers
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【 摘 要 】

Background and objective: The G-Branch endograft is a novel multibranched “off-the-shelf” device used to repair thoracoabdominal aortic aneurysms (TAAAs). This report describes the hemodynamic and morphological performance of the G-Branch endograft in a human patient with TAAA.Materials and methods: We retrospectively reviewed the computed tomography angiography scans and clinical data of a woman in whom TAAA was treated using a G-Branch endograft. Patient-specific three-dimensional models were reconstructed, and computational fluid dynamics and morphological and hemodynamic indicators were analyzed before and after implantation of the device.Results: From a morphological perspective, there was an increase in cross-sectional area in the G-Branch endograft and all bridging stent grafts over time. Blood flow was redistributed among the renovisceral arteries, with a decrease in flow rate in the celiac artery and an increase in the left renal artery. Laminar blood flow was smoother and more rapid after implantation of the G-Branch device and remained stable during follow-up. In the bridging stent grafts, flow recirculation zones were found in the bridging zones of the celiac artery and superior mesenteric artery as well as the distal sealing zones of both renal arteries. Furthermore, higher time-averaged wall shear stress and a lower oscillatory index and relative resident time were found in the G-Branch endograft and bridging stent grafts. Quantitative analysis showed obvious reduction in the surface area ratio of the elevated time-averaged wall shear stress area and surface area ratio of the relative resident time after G-branch implantation.Conclusion: The revascularization of branch vessels occurred following G-branch implantation, with improvements arising not only from morphological changes but also from hemodynamic alterations. The long-term performance of the G-Branch endograft needs further investigation and clinical validation.

【 授权许可】

Unknown   
Copyright © 2023 Wang, Fan, Zhang, Ge, Lu, Liu, Rong and Guo.

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