The relationship between endogenous oxytocin and vasopressin levels and the Prader-Willi syndrome behaviour phenotype

Frontiers in Endocrinology

Endocrinology

James C. Harris¹  C. Sue Carter²  Hans P. Nazarloo²  Stewart L. Einfeld³  Lauren J. Rice⁴  Josephine Agu⁵  Habiba Naanai⁵ 

[1] Department of Psychiatry and Behavioural Sciences and Paediatrics, Johns Hopkins University, Baltimore, MD, United States;Department of Psychology, University of Virginia, Charlottesville, VA, United States;Kinsey Institute, Indiana University, Bloomington, IN, United States;Faculty of Medicine and Health, Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia;Faculty of Medicine and Health, Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia;Faculty of Medicine and Health, Specialty of Child and Adolescent Health, The University of Sydney Children’s Hospital Westmead Clinical School, Sydney, NSW, Australia;Faculty of Medicine and Health, Specialty of Child and Adolescent Health, The University of Sydney Children’s Hospital Westmead Clinical School, Sydney, NSW, Australia;

关键词: Prader-Willi syndrome;    oxytocin;    vasopressin;    behaviour;    plasma;    saliva;   

DOI  :  10.3389/fendo.2023.1183525

 received in 2023-03-10, accepted in 2023-05-09,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundOxytocin and vasopressin systems are altered in Prader Willi syndrome (PWS). However, investigations into endogenous oxytocin and vasopressin levels as well as clinical trials evaluating the effect of exogenous oxytocin on PWS symptoms have had mixed results. It is also unknown whether endogenous oxytocin and vasopressin levels are associated with certain PWS behaviours.MethodWe compared plasma oxytocin and vasopressin and saliva oxytocin levels in 30 adolescents and adults with PWS to 30 typically developing age-matched controls. We also compared neuropeptide levels between gender and genetic subtypes within the PWS cohort and examined the relationship between neuropeptide levels and PWS behaviours.ResultsWhile we did not measure a group difference in plasma or saliva oxytocin levels, plasma vasopressin was significantly lower in individuals with PWS compared to controls. Within the PWS cohort, saliva oxytocin levels were higher in females compared to males and individuals with the mUPD compared to the deletion genetic subtype. We also found the neuropeptides correlated with different PWS behaviours for males and females and for genetic subtypes. For the deletion group, higher plasma and saliva oxytocin levels were related to fewer behaviour problems. For the mUPD group, higher plasma vasopressin levels were related to more behaviour problems.ConclusionThese findings support existing evidence of a vasopressin system defect in PWS and for the first time identify potential differences in the oxytocin and vasopressin systems across PWS genetic subtypes.

【 授权许可】

Unknown   
Copyright © 2023 Rice, Agu, Carter, Harris, Nazarloo, Naanai and Einfeld