Biological functions of the Olig gene family in brain cancer and therapeutic targeting

Frontiers in Neuroscience

Neuroscience

Jenny I. Szu¹  Alexander Wojcinski²  Santosh Kesari²  Igor F. Tsigelny³ 

[1]Department of Translational Neurosciences, Providence Saint John’s Health Center, Saint John’s Cancer Institute, Santa Monica, CA, United States

[2]Department of Translational Neurosciences, Providence Saint John’s Health Center, Saint John’s Cancer Institute, Santa Monica, CA, United States

[3]Pacific Neuroscience Institute, Santa Monica, CA, United States

[4]San Diego Supercomputer Center, University of California, San Diego, San Diego, CA, United States

[5]CureScience, San Diego, CA, United States

关键词: Olig;    transcription factor;    cancer;    glioblastoma;    glioma;    medulloblastoma;    leukemia;    melanoma;   

DOI  :  10.3389/fnins.2023.1129434

 received in 2022-12-21, accepted in 2023-04-26,  发布年份 2023

来源: Frontiers

【 摘 要 】

The Olig genes encode members of the basic helix–loop–helix (bHLH) family of transcription factors. Olig1, Olig2, and Olig3 are expressed in both the developing and mature central nervous system (CNS) and regulate cellular specification and differentiation. Over the past decade extensive studies have established functional roles of Olig1 and Olig2 in development as well as in cancer. Olig2 overexpression drives glioma proliferation and resistance to radiation and chemotherapy. In this review, we summarize the biological functions of the Olig family in brain cancer and how targeting Olig family genes may have therapeutic benefit.

【 授权许可】

Unknown   
Copyright © 2023 Szu, Tsigelny, Wojcinski and Kesari.