Radiation therapy for prostate cancer in Syrian refugees: facing the need for change

Frontiers in Public Health

Public Health

Banu Atalar¹  Peter Orio²  Mutlay Sayan²  Shalini Moningi²  Fatma Teke³  Ayfer Ay Eren⁴  Beyhan Ceylaner Bicakci⁴  Tugce Kutuk⁵  Mehmet Fuat Eren⁶  Lara Hathout⁷  Sarah S. Kilic⁸  Sedenay Oskeroglu Kaplan⁹ 

[1] Acibadem Maslak Hospital, Istanbul, Türkiye;Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States;Dicle University, Diyarbakır, Türkiye;Istanbul Kartal Dr.Lutfi Kirdar Education and Research Hospital, Istanbul, Türkiye;Malatya Education and Research Hospital, Malatya, Türkiye;Marmara University Istanbul Pendik Education and Research Hospital, Istanbul, Türkiye;Rutgers Cancer Institute of New Jersey, The State University of New Jersey, New Brunswick, NJ, United States;Taussig Cancer Institute, Cancer Center, Cleveland Clinic, Cleveland, OH, United States;Şanlıurfa Mehmet Akif İnan Eğitim ve Araştırma Hastanesi, Sanliurfa, Türkiye;

关键词: prostate cancer;    global health;    refugee;    radiation therapy;    Syria;    Turkey;   

DOI  :  10.3389/fpubh.2023.1172864

 received in 2023-02-24, accepted in 2023-05-11,  发布年份 2023

来源: Frontiers

【 摘 要 】

PurposeTo report the utilization of radiation therapy in Syrian refugee patients with prostate cancer residing in Turkey.Methods and materialsA multi-institutional retrospective review including 14 cancer centers in Turkey was conducted to include 137 Syrian refugee patients with prostate cancer treated with radiation therapy (RT). Toxicity data was scored using the National Cancer Institute Common Terminology Criteria for Adverse Events version 3.0. Noncompliance was defined as a patient missing two or more scheduled RT appointments.ResultsAdvanced disease, defined as stage III or IV, was reported in 64.2% of patients while androgen deprivation therapy (ADT) was only administrated to 20% of patients. Conventionally fractionated RT with a median number of 44 fractions was delivered to all patients with curative intent (n = 61) while palliative RT (n = 76) was delivered with a median number of 10 fractions. The acute grade 3–4 toxicity rate for the entire cohort was 16%. Noncompliance rate was 42%.ConclusionMost Syrian refugee prostate cancer patients presented with advanced disease however ADT was seldom used. Despite the low treatment compliance rate, conventional fractionation was used in all patients. Interventions are critically needed to improve screening and increase the use of standard-of-care treatment paradigms, including hypofractionated RT and ADT.

【 授权许可】

Unknown   
Copyright © 2023 Eren, Kilic, Eren, Kaplan, Teke, Kutuk, Bicakci, Hathout, Moningi, Orio, Atalar and Sayan.