Frontiers in Endocrinology | |
Local tumor destruction and liver resection increase overall survival in intermediate/advanced hepatocellular carcinoma patients: evidence from a population-based study | |
Endocrinology | |
Minjie Duan1  Yang Zhang1  Christy Huang2  Scott Lowe3  Guangliang Liu4  Xiaozhu Liu4  Dazhi Ke5  Yi Zhang5  Taiyu He6  Junyi Cao7  Jian Huang8  | |
[1] College of Medical Informatics, Chongqing Medical University, Chongqing, China;College of Osteopathic Medicine, California Health Sciences University, Clovis, CA, United States;College of Osteopathic Medicine, Kansas City University, Kansas, MO, United States;Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China;Department of General Practice, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China;Department of Infectious Diseases, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China;Department of Medical Quality Control, The First People’s Hospital of Zigong City, Zigong, China;Graduate School, Guangxi University of Chinese Medicine, Nanning, China; | |
关键词: liver resection; local tumor destruction; hepatocellular carcinoma; survival; nomogram; | |
DOI : 10.3389/fendo.2023.1191822 | |
received in 2023-03-22, accepted in 2023-07-03, 发布年份 2023 | |
来源: Frontiers | |
【 摘 要 】
BackgroundLiver resection (LR) and local tumor destruction (LTD) are effective treatments, but not commonly recommended for patients with intermediate/advanced hepatocellular carcinoma (HCC). This study aimed to explore whether LR/LTD could improve overall survival (OS) of these patients, and to identify the patients who will most likely benefit from LR/LTD.MethodsData of patients with intermediate/advanced HCC between 2001 and 2018 were extracted from Surveillance, Epidemiology, and End Results database. OS was compared between HCC patients who received LR/LTD and those who did not. A nomogram was constructed for predicting OS, and it was then validated.ResultsA total of 535 eligible patients were included, among which 128 received LR/LTD while 407 did not. Significantly higher OS in patients who received LR/LTD was observed (P<0.001). Based on independent prognostic factors obtained from univariate and multivariate analyses, a nomogram was constructed. The C-indices of nomogram were higher than those of the TNM staging system (training cohort: 0.74 vs. 0.59; validation cohort: 0.78 vs. 0.61). Similarly, areas under receiver operating characteristic curves and calibration curves indicated good accuracy of the nomogram. Decision curve analysis curves revealed good clinical practicability of the nomogram. Furthermore, low-risk patients (nomogram score: 0-221.9) had higher OS compared with high-risk patients (nomogram score: higher than 221.9) (P<0.001).ConclusionLR/LTD significantly improves OS in patients with intermediate/advanced HCC. The nomogram developed in the present study shows high predicating value for OS in patients with intermediate/advanced HCC, which might be useful in selecting patients who are most suitable for LR/LTD.
【 授权许可】
Unknown
Copyright © 2023 Zhang, Zhang, He, Liu, Duan, Huang, Huang, Lowe, Ke, Liu and Cao
【 预 览 】
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