Laser-activated nanoparticles for ultrasound/photoacoustic imaging-guided prostate cancer treatment

Frontiers in Bioengineering and Biotechnology

Bioengineering and Biotechnology

Weili Zhang¹  Yang Cao¹  Linkang Xiao²  Junyong Dai³  Yunfang Wu⁴ 

[1] Chongqing Key Laboratory of Ultrasound Molecular Imaging, Institute of Ultrasound Imaging, Department of Urology Surgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China;Chongqing Key Laboratory of Ultrasound Molecular Imaging, Institute of Ultrasound Imaging, Department of Urology Surgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China;Chongqing General Hospital, Chongqing, China;Chongqing Key Laboratory of Ultrasound Molecular Imaging, Institute of Ultrasound Imaging, Department of Urology Surgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China;Chongqing University Cancer Hospital, Chongqing, China;Chongqing Key Laboratory of Ultrasound Molecular Imaging, Institute of Ultrasound Imaging, Department of Urology Surgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China;Chongqing Wanzhou District Maternal and Child Health Hospital, Chongqing, China;

关键词: laser-activated nanoparticles;    photothermal therapy (PPT);    photoacoustic imaging (PAI);    ultrasound;    prostate cancer;   

DOI  :  10.3389/fbioe.2023.1141984

 received in 2023-01-11, accepted in 2023-03-13,  发布年份 2023

来源: Frontiers

【 摘 要 】

Prostate cancer (PCa) is the most common malignant tumor in men. Prostate-specific membrane antigen (PSMA), which is overexpressed on the surface of Prostate cancer cells, may serve as a potential therapeutic target. Recently, image-guided and targeted therapy for prostate cancers has attracted much attention by using Prostate-specific membrane antigen targeting nanoparticle. In this study, we produced PSMA-targeted light-responsive nanosystems. These nanosystems of liquid perfluorocarbon cores and polymer shells were loaded with the photosensitizer IR780 and therapeutic drugs paclitaxel. The liquid perfluorocarbon (PFP) in nanoparticles can perform ultrasound-enhanced imaging by liquid-gas transition and promote the deliver and release of paclitaxel. IR780 can perform photothermal therapy (PTT) guided by photoacoustic (PA) imaging. Combination treatment with photothermal therapy and chemotherapy exhibited excellent inhibition of cell proliferation in vitro and a significant therapeutic effect in vivo. In conclusion, we successfully formulated PSMA-targeted nanosystems with precision targeting and ultrasound/PA dual-modality imaging for anti-tumor effects.

【 授权许可】

Unknown   
Copyright © 2023 Xiao, Wu, Dai, Zhang and Cao.