Exploration of the core gene signatures and mechanisms between NAFLD and sarcopenia through transcriptomic level

Frontiers in Endocrinology

Endocrinology

Ziyan Tian¹  Zihui Yu¹  Shang Li²  Fuping You³  Jing Yuan³  Ziying Xu⁴ 

[1] Department of Bacteriology, Capital Institute of Pediatrics, Beijing, China;Department of Orthopedics, General Hospital of Chinese People's Liberation Army of China (PLA), Beijing, China;National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, Beijing, China;School of Basic Medical Sciences, Peking University, Beijing, China;School of Basic Medical Sciences, Peking University, Beijing, China;Department of Bacteriology, Capital Institute of Pediatrics, Beijing, China;

关键词: NAFLD (non-alcoholic fatty liver disease);    sarcopenia;    high throughput sequencing;    bioinformatics analyses;    co-expressed genes;   

DOI  :  10.3389/fendo.2023.1140804

 received in 2023-01-09, accepted in 2023-02-27,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionThe increased prevalence of non-alcoholic fatty liver disease (NAFLD) and sarcopenia among the elderly are facing a significant challenge to the world’s health systems. Our study aims to identify the coexpressed genes in NAFLD and sarcopenia patients.MethodsWe downloaded the transcriptome data of NAFLD tissue from patients, as well as muscle tissues from sarcopenia patients, from the GEO database in order to investigate the shared transcriptional regulation mechanisms between these two diseases. Then, focusing on the genes that were frequently expressed in these diseases, together with GSVA and WGCNA, we utilized a range of analysis methods to identify the main co-expressed genes in both diseases by taking intersections. We investigated these changes after learning that they mostly affected lipid metabolism and oxidative stress injury pathways.ResultsBy analyzing these genes and their interactions with transcription factors and proteins, we were able to identify 8 genes that share common patterns. From these 8 genes, we were possible to forecast potential future medicines. Our research raises the possibility of NAFLD and sarcopenia transcriptome regulatory pathways in aging populations.DiscussionIn conclusion, a complete transcription pattern mapping was carried out in order to identify the core genes, underlying biological mechanisms, and possible therapeutic targets that regulate aging in NAFLD and sarcopenia patients. It provides novel insights and proof in favor of decreasing the increased prevalence of sarcopenia in the elderly caused by NAFLD.

【 授权许可】

Unknown   
Copyright © 2023 Xu, Yu, Li, Tian, Yuan and You