Self-assembled nanoparticles: A new platform for revolutionizing therapeutic cancer vaccines

Frontiers in Immunology

Immunology

Changchang Lu¹  Fanyan Meng¹  Tianyu Shi¹  Mengna Sun¹ 

[1] The Comprehensive Cancer Centre of Nanjing Drum Tower Hospital, Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China;The Comprehensive Cancer Centre of Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China;

关键词: cancer vaccines;    nanoparticles;    adjuvant;    self-assembled;    immunotherapies;   

DOI  :  10.3389/fimmu.2023.1125253

 received in 2022-12-16, accepted in 2023-02-07,  发布年份 2023

来源: Frontiers

【 摘 要 】

Cancer vaccines have had some success in the past decade. Based on in-depth analysis of tumor antigen genomics, many therapeutic vaccines have already entered clinical trials for multiple cancers, including melanoma, lung cancer, and head and neck squamous cell carcinoma, which have demonstrated impressive tumor immunogenicity and antitumor activity. Recently, vaccines based on self-assembled nanoparticles are being actively developed as cancer treatment, and their feasibility has been confirmed in both mice and humans. In this review, we summarize recent therapeutic cancer vaccines based on self-assembled nanoparticles. We describe the basic ingredients for self-assembled nanoparticles, and how they enhance vaccine immunogenicity. We also discuss the novel design method for self-assembled nanoparticles that pose as a promising delivery platform for cancer vaccines, and the potential in combination with multiple therapeutic approaches.

【 授权许可】

Unknown   
Copyright © 2023 Shi, Sun, Lu and Meng