Neuroinflammatory disorders of the brain and inner ear: a systematic review of auditory function in patients with migraine, multiple sclerosis, and neurodegeneration to support the idea of an innovative ‘window of discovery’

Frontiers in Neurology

Neurology

Anja Giesemann¹  Marta Altieri²  Athanasia Warnecke³  Daniela Messineo⁴  Massimo Ralli⁵  Teresa Frohman⁶  Elliot M. Frohman⁶  Arianna Di Stadio⁷  Pietro De Luca⁸  Hans-Peter Hartung⁹  Nehzat Koohi^1,10  Diego Kaski^1,10 

[1] Department of Interventional Neuroradiologie, Hannover Medical School, Hannover, Germany;Department of Neurology, University Sapienza, Rome, Italy;Department of Otolaryngology-Head and Neck Surgery, Hannover Medical School, Hannover, Germany;Department of Radiology and Pathology, University Sapienza, Rome, Italy;Department of Sense Organs, University Sapienza, Rome, Italy;Distinguished Senior Fellows (Sabbatical), Laboratory of Neuroimmunology of Professor Lawrence Steinman, Stanford University School of Medicine, Palo Alto, CA, United States;GF Ingrassia Department, University of Catania, Catania, Italy;IRCCS Santa Lucia, Rome, Italy;Head and Neck Department, San Giovanni-Addolorata Hospital, Rome, Italy;Klinik für Neurologie UKD Heinrich Heine Universität Düsseldorf, Düsseldorf, Germany;The UCL Queen Square Institute of Neurology, London, United Kingdom;

关键词: inner ear;    neuroinflammation;    CSF;    Parkinson’s disease;    multiple sclerosis;    headache;   

DOI  :  10.3389/fneur.2023.1204132

 received in 2023-04-11, accepted in 2023-07-24,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundHearing can be impaired in many neurological conditions and can even represent a forme fruste of specific disorders. Auditory function can be measured by either subjective or objective tests. Objective tests are more useful in identifying which auditory pathway (superior or inferior) is most affected by disease. The inner ear’s perilymphatic fluid communicates with the cerebrospinal fluid (CSF) via the cochlear aqueduct representing a window from which pathological changes in the contents of the CSF due to brain inflammation could, therefore, spread to and cause inflammation in the inner ear, damaging inner hair cells and leading to hearing impairment identifiable on tests of auditory function.MethodsA systematic review of the literature was performed, searching for papers with case–control studies that analyzed the hearing and migraine function in patients with neuro-inflammatory, neurodegenerative disorders. With data extracted from these papers, the risk of patients with neurological distortion product otoacoustic emission (DPOAE) was then calculated.ResultsPatients with neurological disorders (headache, Parkinson’s disease, and multiple sclerosis) had a higher risk of having peripheral auditory deficits when compared to healthy individuals.ConclusionExisting data lend credence to the hypothesis that inflammatory mediators transmitted via fluid exchange across this communication window, thereby represents a key pathobiological mechanism capable of culminating in hearing disturbances associated with neuroimmunological and neuroinflammatory disorders of the nervous system.

【 授权许可】

Unknown   
Copyright © 2023 Di Stadio, De Luca, Koohi, Kaski, Ralli, Giesemann, Hartung, Altieri, Messineo, Warnecke, Frohman and Frohman.