Small molecules targeting endocytic uptake and recycling pathways

Frontiers in Cell and Developmental Biology

Cell and Developmental Biology

Clara Mattu¹  Gianluca Ciardelli²  Carlo C. Campa³  Giampaolo Placidi⁴ 

[1] Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy;Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy;Chemical-Physical Processes, National Research Council (CNR-IPCF), Pisa, Italy;Italian Institute for Genomic Medicine, Candiolo, Italy;Candiolo Cancer Institute, Candiolo, Italy;Italian Institute for Genomic Medicine, Candiolo, Italy;Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy;

关键词: endocytosis;    endocytic recycling;    small molecules;    inhibitors;    mechanism of action;   

DOI  :  10.3389/fcell.2023.1125801

 received in 2022-12-16, accepted in 2023-02-23,  发布年份 2023

来源: Frontiers

【 摘 要 】

Over the past years a growing number of studies highlighted the pivotal role of intracellular trafficking in cell physiology. Among the distinct transport itineraries connecting the endocytic system, both internalization (endocytosis) and recycling (endocytic recycling) pathways were found fundamental to ensure cellular sensing, cell-to-cell communication, cellular division, and collective cell migration in tissue specific-contexts. Consistently, the dysregulation of endocytic trafficking pathways is correlated with several human diseases including both cancers and neurodegeneration. Aimed at suppress specific intracellular trafficking routes involved in disease onset and progression, huge efforts have been made to identify small molecule inhibitors with suitable pharmacological properties for in vivo administration. Here, we review most used drugs and recently discovered small molecules able to block endocytosis and endocytic recycling pathways. We characterize such pharmacological inhibitors by emphasizing their target specificity, molecular affinity, biological activity and efficacy in both in vitro and in vivo experimental models.

【 授权许可】

Unknown   
Copyright © 2023 Placidi, Mattu, Ciardelli and Campa.