Pilot testing the EARS-Vet surveillance network for antibiotic resistance in bacterial pathogens from animals in the EU/EEA

Frontiers in Microbiology

Microbiology

Cristina Ballesteros¹  Cristiana Teixeira Justo¹  Cristina Muñoz Madero¹  Eric Zini²  Rosemarie Slowey³  Kevin Kenny³  Peter Damborg⁴  Heike Kaspar⁵  Suvi Nykäsenoja⁶  Tarja Pohjanvirta⁶  Thomas Grönthal⁶  Gudrun Overesch⁷  Babette Klein⁸  Elisabeth Müller⁸  Agnese Lupo⁹  Marisa Haenni⁹  Jean-Yves Madec⁹  Géraldine Cazeau^1,10  Jean-Philippe Amat^1,10  Nathalie Jarrige^1,10  Lucie Collineau^1,10  Justine Lagrange^1,11  Eric Jouy^1,12  Oskar Nilsson^1,13  Karl Pedersen^1,13  Madelaine Norström^1,14  Anne Margrete Urdahl^1,14  Christos Zafeiridis^1,15  Charlotte Mark Salomonsen^1,16 

[1] Agencia Española de Medicamentos y Productos Sanitarios, Madrid, Spain;AniCura Istituto Veterinario Novara, Granozzo con Monticello, Italy;Vetsuisse Faculty, Clinic for Small Animal Internal Medicine, Zurich, Switzerland;Department of Animal Medicine, Production and Health, University of Padova, Padua, Italy;Department of Agriculture, Food and the Marine Laboratories, Celbridge, Ireland;Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark;Federal Office of Consumer Protection and Food Safety, Berlin, Germany;Finnish Food Authority, Helsinki, Finland;Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Bern, Switzerland;Laboklin GmbH & Co. KG, Bad Kissingen, Germany;Laboratory of Lyon, Antimicrobial Resistance and Bacterial Virulence Unit, French Agency for Food, Environmental and Occupational Health & Safety (ANSES), University of Lyon, Lyon, France;Laboratory of Lyon, Epidemiology and Surveillance Support Unit, French Agency for Food, Environmental and Occupational Health & Safety (ANSES), University of Lyon, Lyon, France;Laboratory of Lyon, Epidemiology and Surveillance Support Unit, French Agency for Food, Environmental and Occupational Health & Safety (ANSES), University of Lyon, Lyon, France;Claude Bernard University of Lyon 1, Lyon, France;Laboratory of Ploufragan-Plouzané-Niort, Mycoplasmology, Bacteriology and Antimicrobial Resistance Unit, French Agency for Food, Environmental and Occupational Health & Safety (ANSES), Ploufragan, France;National Veterinary Institute of Sweden, Uppsala, Sweden;Norwegian Veterinary Institute, Ås, Norway;Seconded National Expert to the European Commission (DG Health and Food Safety), Ministry of Rural Development and Food of Greece, General Directorate of Veterinary Services, Athens, Greece;Veterinary Laboratory, Danish Agriculture & Food Council F.m.b.A., Copenhagen, Denmark;

关键词: antimicrobial resistance;    veterinary clinical pathogens;    monitoring;    integrated surveillance;    One Health;   

DOI  :  10.3389/fmicb.2023.1188423

 received in 2023-03-17, accepted in 2023-04-27,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionAs part of the EU Joint Action on Antimicrobial Resistance (AMR) and Healthcare-Associated Infections, an initiative has been launched to build the European AMR Surveillance network in veterinary medicine (EARS-Vet). So far, activities included mapping national systems for AMR surveillance in animal bacterial pathogens, and defining the EARS-Vet objectives, scope, and standards. Drawing on these milestones, this study aimed to pilot test EARS-Vet surveillance, namely to (i) assess available data, (ii) perform cross-country analyses, and (iii) identify potential challenges and develop recommendations to improve future data collection and analysis.MethodsEleven partners from nine EU/EEA countries participated and shared available data for the period 2016–2020, representing a total of 140,110 bacterial isolates and 1,302,389 entries (isolate-antibiotic agent combinations).ResultsCollected data were highly diverse and fragmented. Using a standardized approach and interpretation with epidemiological cut-offs, we were able to jointly analyze AMR trends of 53 combinations of animal host-bacteria–antibiotic categories of interest to EARS-Vet. This work demonstrated substantial variations of resistance levels, both among and within countries (e.g., between animal host species).DiscussionKey issues at this stage include the lack of harmonization of antimicrobial susceptibility testing methods used in European surveillance systems and veterinary diagnostic laboratories, the absence of interpretation criteria for many bacteria–antibiotic combinations of interest, and the lack of data from a lot of EU/EEA countries where little or even surveillance currently exists. Still, this pilot study provides a proof-of-concept of what EARS-Vet can achieve. Results form an important basis to shape future systematic data collection and analysis.

【 授权许可】

Unknown   
Copyright © 2023 Lagrange, Amat, Ballesteros, Damborg, Grönthal, Haenni, Jouy, Kaspar, Kenny, Klein, Lupo, Madec, Salomonsen, Müller, Madero, Nilsson, Norström, Nykäsenoja, Overesch, Pedersen, Pohjanvirta, Slowey, Justo, Urdahl, Zafeiridis, Zini, Cazeau, Jarrige, Collineau and on behalf of the EARS-Vet network.