Frontiers in Endocrinology | |
Hormone replacement treatment regimen is associated with a higher risk of hypertensive disorders of pregnancy in women undergoing frozen-thawed embryo transfer | |
Endocrinology | |
Ting Wang1  He Cai1  Dan Pan1  Wenhao Shi1  Lijuan Fan1  Xitong Liu1  Na Li1  Xiaofang Li1  Juanzi Shi1  Pengfei Qu2  | |
[1] Assisted Reproduction Center, Northwest Women’s and Children’s Hospital, Xi’an, China;Translational Medicine Center, Northwest Women’s and Children’s Hospital, Xi’an, China; | |
关键词: frozen-thawed embryo transfer; endometrial preparation protocol; hormone replacement treatment; hypertensive disorders of pregnancy; obstetric outcomes; | |
DOI : 10.3389/fendo.2023.1133978 | |
received in 2022-12-29, accepted in 2023-02-13, 发布年份 2023 | |
来源: Frontiers | |
【 摘 要 】
IntroductionIn frozen-thawed embryo transfer (FET) cycles, hormone replacement treatment (HRT) was associated with a higher risk of hypertensive disorders of pregnancy (HDP) compared with natural cycles (NC). Multiple pregnancy was a risk factor for HDP and several studies did not conduct subgroup analysis of singleton pregnancy and multiple pregnancy.ObjectiveTo investigate whether HRT regimen could be a risk factor for HDP in women undergoing FET cycles in singleton and twin pregnancies.MethodsA retrospective cohort study at a tertiary hospital, including a total of 9120 women who underwent FET and achieved ongoing pregnancy; 7590 patients underwent HRT-FET and 1530 NC-FET. The main outcome was HDP. HDP were analyzed for singleton and twin pregnancies, respectively.ResultsIn the singleton pregnancy, the risk of HDP in the HRT-FET group was significantly higher than that in the NC-FET group (6.21% vs. 4.09%; P=0.003). After adjusting for female age oocyte pick up, female age at FET and body mass index (BMI), HRT was found as a risk factor for HDP (adjusted odds ration [aOR]: 1.43; 95% confidence interval [CI]: 1.07 to 1.91; P=0.017). In the multiple pregnancy, the risk of HDP in the HRT-FET and NC-FET groups was similar.ConclusionHRT was associated with a higher risk of HDP in women who underwent FET and achieved singleton pregnancy.
【 授权许可】
Unknown
Copyright © 2023 Fan, Li, Liu, Li, Cai, Pan, Wang, Shi, Qu and Shi
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202310107292920ZK.pdf | 704KB | download |