Hormone replacement treatment regimen is associated with a higher risk of hypertensive disorders of pregnancy in women undergoing frozen-thawed embryo transfer

Frontiers in Endocrinology

Endocrinology

Ting Wang¹  He Cai¹  Dan Pan¹  Wenhao Shi¹  Lijuan Fan¹  Xitong Liu¹  Na Li¹  Xiaofang Li¹  Juanzi Shi¹  Pengfei Qu² 

[1] Assisted Reproduction Center, Northwest Women’s and Children’s Hospital, Xi’an, China;Translational Medicine Center, Northwest Women’s and Children’s Hospital, Xi’an, China;

关键词: frozen-thawed embryo transfer;    endometrial preparation protocol;    hormone replacement treatment;    hypertensive disorders of pregnancy;    obstetric outcomes;   

DOI  :  10.3389/fendo.2023.1133978

 received in 2022-12-29, accepted in 2023-02-13,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionIn frozen-thawed embryo transfer (FET) cycles, hormone replacement treatment (HRT) was associated with a higher risk of hypertensive disorders of pregnancy (HDP) compared with natural cycles (NC). Multiple pregnancy was a risk factor for HDP and several studies did not conduct subgroup analysis of singleton pregnancy and multiple pregnancy.ObjectiveTo investigate whether HRT regimen could be a risk factor for HDP in women undergoing FET cycles in singleton and twin pregnancies.MethodsA retrospective cohort study at a tertiary hospital, including a total of 9120 women who underwent FET and achieved ongoing pregnancy; 7590 patients underwent HRT-FET and 1530 NC-FET. The main outcome was HDP. HDP were analyzed for singleton and twin pregnancies, respectively.ResultsIn the singleton pregnancy, the risk of HDP in the HRT-FET group was significantly higher than that in the NC-FET group (6.21% vs. 4.09%; P=0.003). After adjusting for female age oocyte pick up, female age at FET and body mass index (BMI), HRT was found as a risk factor for HDP (adjusted odds ration [aOR]: 1.43; 95% confidence interval [CI]: 1.07 to 1.91; P=0.017). In the multiple pregnancy, the risk of HDP in the HRT-FET and NC-FET groups was similar.ConclusionHRT was associated with a higher risk of HDP in women who underwent FET and achieved singleton pregnancy.

【 授权许可】

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Copyright © 2023 Fan, Li, Liu, Li, Cai, Pan, Wang, Shi, Qu and Shi