Cellular heterogeneity and plasticity during NAFLD progression

Frontiers in Molecular Biosciences

Molecular Biosciences

Baek-Soo Han¹  Da-Yeon Yang²  Won Kon Kim²  Kwang-Hee Bae²  Kyoung-Jin Oh²  Eun-Woo Lee²  Hyunmi Kim²  Juyoung Choi²  Tae Hyeon An²  Sang Chul Lee²  Hyun-Ju Park² 

[1] Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of Korea;Biodefense Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea;Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea;Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of Korea;

关键词: NAFLD;    heterogeneity;    hepatocytes;    Cholangiocytes;    hepatic stellate cells;    Kupffer cells;    cellular plasticity;    metabolic adaptation;   

DOI  :  10.3389/fmolb.2023.1221669

 received in 2023-05-12, accepted in 2023-07-18,  发布年份 2023

来源: Frontiers

【 摘 要 】

Nonalcoholic fatty liver disease (NAFLD) is a progressive liver disease that can progress to nonalcoholic steatohepatitis (NASH), NASH-related cirrhosis, and hepatocellular carcinoma (HCC). NAFLD ranges from simple steatosis (or nonalcoholic fatty liver [NAFL]) to NASH as a progressive form of NAFL, which is characterized by steatosis, lobular inflammation, and hepatocellular ballooning with or without fibrosis. Because of the complex pathophysiological mechanism and the heterogeneity of NAFLD, including its wide spectrum of clinical and histological characteristics, no specific therapeutic drugs have been approved for NAFLD. The heterogeneity of NAFLD is closely associated with cellular plasticity, which describes the ability of cells to acquire new identities or change their phenotypes in response to environmental stimuli. The liver consists of parenchymal cells including hepatocytes and cholangiocytes and nonparenchymal cells including Kupffer cells, hepatic stellate cells, and endothelial cells, all of which have specialized functions. This heterogeneous cell population has cellular plasticity to adapt to environmental changes. During NAFLD progression, these cells can exert diverse and complex responses at multiple levels following exposure to a variety of stimuli, including fatty acids, inflammation, and oxidative stress. Therefore, this review provides insights into NAFLD heterogeneity by addressing the cellular plasticity and metabolic adaptation of hepatocytes, cholangiocytes, hepatic stellate cells, and Kupffer cells during NAFLD progression.

【 授权许可】

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Copyright © 2023 Park, Choi, Kim, Yang, An, Lee, Han, Lee, Kim, Bae and Oh.