Exploring preferences of different modes of administration of hypomethylating agent treatments among patients with acute myeloid leukemia

Frontiers in Oncology

Oncology

Solene Bayet¹  Ira Arora²  Ana Maria Rodriguez-Leboeuf³  Laurie Batchelder⁴  Stephanie Philpott⁴  Alice Eberhardt⁵  David Bruhn⁶  Audrey Delmas⁷ 

[1] IQVIA, Courbevoie, France;IQVIA, London, United Kingdom;IQVIA, Madrid, Spain;IQVIA, Reading, United Kingdom;Otsuka Pharma GmbH, Frankfurt am Main, Germany;Otsuka Pharmaceutical Development & Commercialization Inc., Rockville, MD, United States;Otsuka Pharmaceutical Europe Ltd., Wexham, United Kingdom;

关键词: acute myeloid leukemia;    hypomethylating agents;    oral treatment;    patient preference;    treatment preference;    qualitative interview;   

DOI  :  10.3389/fonc.2023.1160966

 received in 2023-02-07, accepted in 2023-04-11,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionAbout half of patients with Acute Myeloid Leukemia (AML) are not eligible for Standard Induction Chemotherapy (SIC). Hypomethylating Agents (HMAs) intravenously (IV) or subcutaneously (SC) in a clinical setting are typically offered as an alternative. However, injectable HMAs may be burdensome for patients given the frequent hospital visits and side effects. This study explored patient treatment preferences for different modes of administration (MOA) and the relative importance of treatment-related characteristics that influence treatment decisions.MethodsSemi-structured 1:1 interviews were conducted with 21 adult patients with AML in Germany, the United Kingdom, and Spain, who are not eligible for SIC, had experience with HMAs or were scheduled to be treated with HMAs. After discussing their experience of living with AML and its treatments, patients were presented with hypothetical treatment scenarios to explore their preferences, and a ranking exercise to assess the relative importance of treatment characteristics that influence their treatment-decisions for AML.ResultsMost patients reported an overall preference for oral administration over parenteral routes (71%), mostly due to convenience. Those preferring IV or SC routes (24%) reasoned with faster speed of action and onsite monitoring. When presented with a hypothetical situation of a patient having to choose between two AML treatments that were identical except for their MOA, the majority preferred the oral route (76%). Regarding treatment characteristics that influence treatment decisions, patients most frequently reported efficacy (86%) and side effects (62%) as important, followed by mode of administration (29%), daily life impacts (24%) and location of treatment (hospital versus home) (14%). However, only efficacy and side effects were rated as number one deciding factors (67% and 19%, respectively). Patients most frequently rated dosing regimen (33%) as least important.ConclusionThe insights gained from this study may help support patients with AML who are receiving HMA treatment instead of SIC. A potential oral HMA with similar efficacy and tolerability profiles to injectable HMAs could influence treatment decisions. Furthermore, an oral HMA treatment might decrease the burden of parenteral therapies and improve patients’ overall quality of life. However, the extent of influence MOA has on treatment decisions requires further investigation.

【 授权许可】

Unknown   
Copyright © 2023 Delmas, Batchelder, Arora, Bayet, Bruhn, Eberhardt, Philpott and Rodriguez-Leboeuf