Nitrous oxide: a unique official French addictovigilance national survey

Frontiers in Public Health

Public Health

Amélie Daveluy¹  Arthur Lionnet²  Marylène Guerlais³  Marie Gérardin³  Aurélie Aquizerate³  Edouard-Jules Laforgue⁴  Caroline Victorri-Vigneau⁴  Marion Istvan⁴  Mélanie Duval⁴ 

[1]Centre d’Addictovigilance, Département de Pharmacologie Médicale, INSERM, BPH, U1219, CHU de Bordeaux, Bordeaux, France

[2]Nantes Université, CHU Nantes, Service de Neurologie, Nantes, France

[3]Inserm, U1235, Nantes, France

[4]Nantes Université, CHU Nantes, Service de Pharmacologie Clinique – Centre d’Evaluation et d’Information sur la Pharmacodépendance-Addictovigilance, Nantes, France

[5]Nantes Université, CHU Nantes, Service de Pharmacologie Clinique – Centre d’Evaluation et d’Information sur la Pharmacodépendance-Addictovigilance, Nantes, France

[6]Nantes Université, CHU Nantes, INSERM, methodS in Patient-centered outcomes and HEalth ResEarch, Nantes, France

关键词: nitrous oxide;    substance use disorder;    addictovigilance;    pharmacodependence;    addiction;   

DOI  :  10.3389/fpubh.2023.1167746

 received in 2023-02-16, accepted in 2023-03-31,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionNitrous oxide has become over the last few years a public health problem in many countries. France has a dedicated health monitoring system dedicated to the surveillance of the abuse, dependence and consequences associated with the use of psychoactive substances coordinated by the French National Agency for the Safety of Medicines and Health Products.We present the French national survey of nitrous oxide.Materials and methodsWe analyzed all the cases with nitrous oxide from 2012 to 2021: number of notifications, characteristics of the subjects and consumption, consequences reported and their evolutions over time. In addition, we have made a special focus on the four main complications reported.ResultsA total of 525 cases were received with an exponential increase since 2019. We observed changes in the characteristics of the notifications with an increase in the proportion of women [42.7% in 2021 vs. 30.8% in 2020 (p = 0.02)]; an increase in the quantities consumed (use of cylinders); a negative evolution of the contexts of use with a search for self-therapeutic effects and use in violent contexts; an increasing trend of the severity of cases [78.1% in 2021 vs. 70.0% in 2020 (p = 0.07)].The main effects were substance use disorders and/or associated criteria (82.5%), neurological disorders (75.4%), psychiatric symptoms (15.4%) and cardiovascular events (8.6%). In terms of evolution, we observed a significant increase in cases with a use disorder and an increase in neurological complications. Moreover, new serious effects, notably cardiovascular events were reported.DiscussionThe combination of high availability, varied effects from euphoria to relief of discomfort in a stressful global pandemic context and the development of dependence could explain the rapid growth of consumption and the seriousness of the cases.It must now be taken into account that (i) Substance use disorders are associated with nitrous oxide consumption; (ii) clinicians must consider “nitrous oxide” in young subjects presenting different types of manifestations; and (iii) stopping consumption is imperative and is the first treatment. In this context, an addictological assessment must also be carried out.

【 授权许可】

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Copyright © 2023 Guerlais, Aquizerate, Lionnet, Daveluy, Duval, Gérardin, Istvan, Laforgue and Victorri-Vigneau.